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Development of mini-IGFBP-3 (EP 11 305 197.3 24): Preclinical Proof of concept of its in vivo anti tumor activity – IGF-TRAP
After becoming an attractive therapeutic target in Oncology, IGF axis generated the emergence of new therapeutic agents (monoclonal antibodies or tyrosine kinase inhibitors) targeting IGF-1R some of them being currently evaluated in clinical trials. We explore an alternative approach aimed at neutra
Emergence of New Concept On Depression – ENCOD
Depression is a frequent pathology that can affect 20% of the population of industrialized countries. The economic burden reaches more than 100 millions euros in Europe. The origines of the pathology are numerous as well as the medical treatments. Despite the existence of important therapeutic molec
Copper chelators targeted at the liver: a innovative treatment of hepatic copper overload – COPDETOX
Metal overload plays an important role in several diseases such as Wilson’s disease, a major genetic disorder of copper metabolism in humans. The Wilson’s disease is a rare disease (~ 1000 cases in France, 10000 in the EU and 10000 in the USA) due to the impairment of a protein responsible for the e
beta-CN(94-123), a bioactive peptide from fermented milks strengthening intestinal protection: Promising new treatments for intestinal diseases – b-ACTIPROD
The peptide ß-CN(94-123), derived from bovine beta-casein and identified in yogurt, is a new bioactive peptide targeting two populations of epithelial cells that play a major role in intestinal defense: goblet cells and Paneth cells. The goblet cells produce MUC2, the main component of intestinal mu
Production of cornea from pluripotent stem cells: novel cellular model for drug screening and toxicology and potential for cell therapy. – CORNiPS
Millions of people need cornea for therapeutic transplantation. Post mortem tissue are far from sufficient for the need. Moreover, animals cannot be used anymore to test potential irritative and toxic effects of drugs for therapy. The existing models derived from immortalized cells and thus not sat
TCTP inhibition by specific antisense oligonucleotide lipid moiety-modified as a new therapeutic strategy to restore hormone- and chemosensitivity for the treatment of therapy-resistant prostate cancer and other tumours – TCTP-LASOCaP
One strategy to improve therapies in advanced prostate cancer (PC) involves targeting genes that are activated by androgen withdrawal, either to delay or prevent the emergence of the CR phenotype. Recently, we identified the translationnaly controlled Tumor protein (TCTP) as a highly over-expressed
Validation of an « immune signature » predicting a therapeutic response to anthracyclines in breast cancer. – AP’ONCALYPSE
This grant application aims at validating a series of novel immune biomarkers of response to anthracyclines predicting the capacity of the host to get immunized (and cured) against his tumor with the hindsight to compensate the defects in immune signaling by specific targeted therapies in « predicte
New antibacterial compounds targeting NAD kinase – ANAKIN (Anti-NAd-Kinase)
With emergence of multidrug-resistant pathogens, the need for new antibiotics acting on unexplored targets has never been so important. NAD kinases are essential enzymes in bacteria and attractive targets for the development of selective antibacterial drugs. We recently identified, following a “targ
Establishment of innovative and proprietary methods for the manufacturing and quality control testing of a clinical grade gene therapy vector for the treatment of patients affected with a pigmented retinopathy secondary to a mutation in the pde6ß gene – PDE6-ß
To date, there is no treatment allowing the stabilization or the regeneration of the retina in patients affected by rod-cone dystrophies (Retinitis Pigmentosa). Retinitis Pigmentosa (RP) prevalence is of 1 in 5000 people (more than 50 genes are involved), which is the first cause of hereditary blind
Toward brain-ventilator interface: electroencephalographical recording to assess patient-ventilator interaction in humans – EEG-PVI
One patient out of two in intensive care units is administred mechanical ventilation. Half of these patients experience respiratory discomfort, yet they are ventilated. This is associated with post-traumatic stress disorder occurrence, thus significant psychologic sequellaes. In one third of the pat
Biomarkers of left ventricular remodeling after myocardial post-infarction and heart failure – PHOSTNT
Each year, 150,000 persons die from cardiovascular diseases in France, which is a major cause of mortality in our country and each year 120,000 persons suffer from myocardial infarction while nearly 500,000 patients suffer of heart failure. And left ventricular remodeling after myocardial infarction
Inhibition of Mucus Hypersecretion In COPD Exacerbation – IMHICE
COPD is a debilitating and progressive lung disease. It is characterized by episodes of exacerbations whose incidence and prevalence increases with disease severity. Cigarette smoke is the main etiological factor in the development of COPD. Exacerbations are caused mainly by respiratory infections,
Treatment of Ulcerative Colitis by Targeting Endoplasmic Reticulum Stress – CURRENT
Current treatment of UC are not sufficient to control the disease in long term use as 25-30% of patients are in treatment failure. Our strategy was to compare the non-inflamed colonic mucosa of patients with UC compared to healthy controls in order to seek early abnormalities of mucosa, and develop
Development of a bivalent vaccine against hepatitis B and C viruses – HEPATIBIVAX
The HCV envelope proteins represent good immunogens to develop a prophylactic vaccine against HCV. However, it is very difficult to produce and purifiy these proteins, as they are retained in intracellular compartments. When using truncated forms, they can be secreted but they lose their immunogen
A new pH sensor for water resource – SApHIRE
The European Directive of 2000 and the French Water Act of 2006 established a framework for the protection of water resources. They include the need for self-monitoring and regular checks on natural water, drinking water and waste water to assess the impact of human activities and to protect aquatic
Low-cost Hydrogen Generator based on Proton Exchange Membrane Water Electrolysis Technology – HydroPEM
. . . . Over the past decades, the European Commission has been actively supporting the development of alternative energy carriers such as molecular hydrogen (H2) inside the European Union (EU). In this so-called “hydrogen economy”, H2 would be used (next to electricity) to accelerate EU’s decarboni
Fluorescence Microscopy for membrane imaging – SMARTVIEW
SmartView provides an unmatched axial resolution and real-time membrane topography imaging with nanometer precision. This technology meets the growing needs of users in multimodal fast and ultra-sensitive imaging. This project proposes a novel approach offering a radical departure from traditional t
Validation of anti-ICOS antibody as a drug candidate for anti-tumor immunotherapy through neutralisation of regulatory T cell suppressive activity – VICIT
* validate ICOS as therapeutic target in muirne models using neutralising anti-mICOS antibody and cells expressing ICOS or not. * validate ICOS as therapeutic target in different human solid tumors * validate the therapeutic potential of drug candidiate in a murine humanised model * évaluate me
Chemical and biological optimization and synthesis of novel heterocyclic 4-amino quinoline-gamma-lactam structures as antimalarials. From «hit» to a potential «lead». – QUINOLAC
A new series of compounds that can be useful as chemotherapeutic agents to treat malaria have demonstrated very potent in vitro activity against P. falciparum strains of variable sensitivity. The originality and novelty of the structures have been demosntrated and their syntheses generate some dive
Catalytic preparation of aryl and allylboronic derivatives – BOROCAT
. . . . A novel synthetic methodology to access benzylboronic acids and esters has been developed, involving the coupling of the corresponding benzyl halides and pinacolborane (patent FR 2009 and PCT 2010). The main originality of this method is the use of a catalytic amount of metallic Mg as the
Blend optimization and reagent consumption reduction: development of a pre-industrial prototype based on twin-screw extruder principle for sewage sludge liming – OptiChaux
. . . . Annual French sewage sludge production is around 1.1 million of tons of dry matter. About 60% are used in agriculture. Before spreading, lime is usually added to sludges in order to stabilize them. This process allows olfactory nuisance decrease and fermenting processes reduction. Otherwise,
Nano-DSC: Differential scanning nanocalorimetry for life sciences and nanosciences applications – Nano-DSC
The project concerns the developement of a new generation of miniaturised differential scanning nano-calorimeter (Nano-DSC) for applications in biophysics and nanosciences; the key points are divided into three different axis : *Resol
Fabrication of Amorphous Metal Objects of µSize – FAMOµS
. . . . The size reduction of functional system is a major technical, scientific as well as commercial issue. Microelectronic devices opened the path to miniaturisation and, as a consequence, the technical fields using microelectronic devices had to adapt the size of their components. Moreover, the
Development of a monitoring device of the osseointegration of implants in the osteo-articular system – WaveImplant
The aim of this work program is to be ready for the clinical development of the technology using a prototype in line with the market expectations. The program is going on as expected and no particular difficulty is met. Two persons have been hired and two master students work on the subject. An impo
Reinforcement and enhanced validation of the FROILOC technology (localised cold ultraclean atmosphere) – Froiloc-C
. . . . The FROILOC technology has been developed by Cemagref and has passed a first stage of validation (Technology Readiness level = TRL7). It consists in an air handling system able to deliver a cold and ultraclean air flow localised on work places and machines in the workshops of the food indust
Advanced fail-safe devices and power electronic circuits for critical applications. – FAST-STEP
The reliability of electrical system for power conversion is a forefront challenge for the coming years. In the hearth of this topic, it appears that power electronic converters are involved to provide an increasing role in critical applications (manufacturing, automotive, avionic, nuclear). It is k
Adaptive Optics for Confocal Microscopy – CONFOC-AO
Fluorescence Fluctuations Microscopy (FFM) includes a variety of methods (FC(C)S, RICS, sFCS, PCH, etc..) mainly devoted to biology, which utilize fluorescence fluctuations to calculate the average number of molecules passing through the observation volume of a confocal microscope and obtain inform
Design and realization of a pilot for the control of glass thermo-forming process. – PROTHERMOVERRE
Thermo-forming consists in shaping a piece of glass: a glass sheet is put on a mould initially cold, then during the heating process this sheet is fitting the mould shape. The deformation is governed by gravity and viscosity effects (the glass viscosity is strongly varying with temperature). The the
Validation of lichen derivatives as pro-pigmenting skin compounds – PIGMELICH
UV radiation is the principal aetiologic agent of most skin cancer and a key component of photo ageing. Endogenous systems including pigmentation, skin thickness, antioxydant complex and DNA repair are leading to photo protection. The public health campaigns emphasize the importance of photo protect
Development of two precocious sexing tests for tilapia to be used by farmers and research laboratories – SexTil
In tilapia, all-male populations are beneficial for farmers because males have a faster growth-rate than females and it avoids the constraints associated with reproduction. Considering that a male grows 1.6-fold more than a female after 7 months of farming and that tilapia annual production is 34 mi
Immunoenzymatic assay for the detection of circulatory antigens in the course of infection by Toxoplasma gondii – TOXOCAg
The diagnosis of toxoplasmosis relies on the detection of specific antibodies. This diagnosis is not appropriated to patients suffering from reactivation of their congenital infection but without antibodies rebound or to immunodeficient patients. The diagnosis tests may also lack sensitivity for wom
Probe for compact Near Field Optical Microscope – SIROCO
Scanning near fiel optical microscopy is still little-used in life sciences despite of the fact that the technique has a great potential to answer to issues, particularly when high optical resolution is needed and for localized interactions studies. This is probably due to experimental implementati
High Performances Embedded Measurement Systems for multiDegrees of Freedom Microsystems – MyMeSys
The objectives of MiMeSys is to study and develop a multi-axis, embeddable, highly accurate and high bandwidth micromanipulators based on integrated position and force sensors and control strategies. The results are going to accelerate the development of high precision, high throughput micromanipula
Fast Atom Diffraction applied to real time monitoring of epitaxial growth – GIFAD-II
Molecular beam epitaxy (MBE) is the method of choice for producing high performance devices for microelectronic and optoelectronic applications. The success of MBE lies in part in the use of RHEED (Reflection High Energy Electron Diffraction) for the real time monitoring of the growth. Yet, RHEED be
distributed clock synChrONization for future loNg distancE Quantum crypTography – CONNEQT
In the process of economic globalization, information security has become more and more important for both organizations and individuals. Security of classical cryptography is based on the complexity of cipher algorithms proven to be non robust against the progress of future computational resources.
Self-mixing displacement sensor – CALDIRO
Our project aims to develop a miniaturized and cost-efficient laser sensor for displacement and vibration measurements and related applications: modal analysis, impact detection, ageing in materials... The Research group OSE of the LAAS-CNRS is leading this project with the support of the PRES Unive
Development and characterization of materials like aluminum architected - iron for their industrialization – ALUARMé
Improving the characteristics of objects or machine parts, or, increasing performance of machines or systems is either by improving the design, either through improved materials or though materials designed integrating different functions or properties. We are working on developing materials that re
EASEA Massively Parallel Platform for Cloud Computing – EASEA-CLOUD
The aim of the EASEA-CLOUD project is to exploit the massively parallel resources that are offered by clusters or a grid of modern GPU-equipped machines in order to find solutions to inverse problems whose evaluation function can be intrinsically sequential. Exploiting massively parallel machines
Towards the first demonstator for a new non-volatile memory class based on Mott insulator AM4X8 – Mott-RAM
Three main task have been defined: Task 1: Optimization of the deposition process and crystalline quality of the thin layers Task 2: Miniaturization of the electrical contacts task 3: - downscaling effect demonstration: Ron/Roff ratio is increased by a factot 10000 while decreasing the contac
ELECtrical NANO-imPRINT for the industrial fabrication of nanoparticle-based sensors – ELECNANOPRINT
test test test test Many countries including France have recently launched ambitious R&D programs in order to promote the emergence of nanotechnologies. This strong interest is caused by the exploration of the innovative properties of nano-objects that could lead to many potential applications. For
Haptic device for machining tool path computation on multi-axes machine tool and robot – ADHOC
This project is designed to interface a haptic arm of entry-level CAD / CAM software for: - Simplify the ergonomics of tool path computation of manufacturing operations; - Instantly evaluate the kinematic behavior of used the machine tool or robot and correct problems of calculation of joint coo
Yourcast : Enjoy personalized broadcasting signage – YourCast
Nowadays dynamic signage in public and private areas fully contributes to people information, either using supplementary information on handheld devices or not. Dynamic signage results from a technological convergence between the advent of Web 2.0 and the reinforcement of electronic uses. By deliver
Design and prototyping of an all-optical teraHertz vision system using Thermal converter – TeraVision
The main goal of this project is the development of a new prototype of THz camera. The idea is to increase the performance of such system in order to create a prototype devoted to industrail applications The first results allow us to optimize the conception of the prototype and then to create the fi
RealFluids – RealFluids
The code FluidBox is a non-specialized platform for compressible fluids flows simulation. The targeted fluids can be of very different nature and are characterized by their state. A version of this software is at present downloadable under open source license CeCILL-C in the INRIA’s GForge (https
Supramolecular TriArylamine NanoWires as metal-like active layers for organic electronics – STANWs
Our daily life will be more and more surrounded by electronic devices involving organic components being flexible, biocompatible, multifunctional, energy friendly, cheap, and of growing impact for consumer and portable electronics. Recently, we have found that i) organic interconnects involving a ne
Development of new cardioprotective drugs – Cardioprotection
Anthracyclines, rank among the most effective anticancer drugs ever developed. However, their clinical use is limited by acute and chronic cardiotoxicities. We have for several years investigated the properties of synthetic analogues of natural compounds called flavaglines. We demonstrated that the
Production process of dissymmetric particles using bipolar electrochemistry – PROJANUS
Janus particles are dissymmetric objects with a large variety of potential applications, ranging from nanoelectronics to medicine. The main goal of the present project is to propose a coherent strategy for the development of an industrial process in the field of nanotechnology, allowing a large scal
All-fibered Optical Sources for Telecommunication Applications – SO FAST
Most of the telecommunication operators now offer number and number of services at higher and higher bit rates, involving the deployment of all-optical techniques until the user home (FFTH: Fiber To The Home). This strong increase of the global bit rate in the access networks (1 Gbit/s available to
Development of a holographic laser Doppler imaging device for non-invasive and non-ionizing blood microflow screening in real-time. – VideoLaserDoppler
Vascular diseases are among the leading causes of death in developed countries, including the complications of diabetes and hypertension. These diseases particularly affect small vessels, that is to say the microcirculation, for which diagnostic methods are very limited. The impact of the retinal bl
Integrated optic Static OCT based on LLIFTS – OCT-LLIFTS
The aim of this project is the design and the realisation of an OCT (Optical Coherence Tomograph) demonstrator compact and fully static. This demonstrator associates an optical glass integrated chip with a large bandwith optical source and a linear camera. This system will have a cost drastically le
Monolithic white LED for solid state lighting – DELMONO