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Fluorescence Microscopy for membrane imaging – SMARTVIEW

Innovating bio-imaging technique for cell investigation

SmartView is a development project for biomedical microscopy equipment. It is based on an innovative patented technology and is intended for imaging platforms, laboratories as well as biomedical institutes in the fields of health, food, pharmaceutical and cosmetics.

Issues in many key areas

SmartView provides an unmatched axial resolution and real-time membrane topography imaging with nanometer precision. This technology meets the growing needs of users in multimodal fast and ultra-sensitive imaging. This project proposes a novel approach offering a radical departure from traditional techniques. In addition, the system can be implemented on any commercial fluorescence microscope and will bring new functionality while maintaining the standard functionalities. This multifunctionality is a substantial step forward in understanding the mechanisms of life. Finally, this technology allows to operate with a non-specific illumination while alternative techniques require a laser leading to additional costs and a non-uniform illumination field.

SmartView provides unparalleled axial resolution and also provides real-time membrane topography with nanometer precision. This technology field meets the growing needs of users in multimodal fast and ultra-sensitive imaging. This project proposes a disruptive approach with traditional techniques. In addition, the system can be implemented on any commercial fluorescence microscope and will bring new functionality while maintaining the standard parallel imaging. This multifunctionality is a substantial step forward in understanding the mechanisms of life. Finally, this technology allows to operate with a non-specific lighting while current offers require a laser light leading to additional costs and a non-uniform illumination field.

A demonstrator that can be mounted on any commercial microscope is now operational. This module allows one to make a new membrane imaging in parallel with the normal use of the microscope. The first experiments in the biomedical field are underway, particularly with studies on Alzheimer's disease. The results are promising. Coupling with other imaging techniques including super-resolved techniques is in the study. Industrial partnerships are being negotiated in order to commercialize this new technique.

The implementation of this technique has resulted in significant improvements to now offer unmatched performance particularly in terms of sensitivity and resolution. This progress was made ??in conjunction with a better understanding of the theoretical principles. This has now led to the definition of a new class of imaging paving the way for multiple original implementations that will provide a wide range of new features.

This project has resulted in several published articles in international journals (Optic Letters, Physical Review Letters) and communications in international conferences. This innovative techniques was awarded the Prix Jean Jerphagnon 2012.

The aim of SmartView project is to develop equipment biomedical microscopy. It is based on an innovative and patented technology. It is for imaging platform, research and development laboratorys as well as biomedical institutes in the fields of medicine and health, food, pharmaceutical and cosmetic industries. It is part of the market of optical super-resolution microscopy for biology, this sector weighs $ 280 million in 2010 with a significant growth rate of 12%.

SMARTviewer proposes a new microscopy for real-time observation of cell adhesion and membrane phenomena. This innovative microscopy, simple to implement, is compatible with any type of fluorescence microscope. It provides an unparalleled axial resolution and a real-time topography of the membrane with nanometer precision. This wide field imaging technology meets the growing needs of users for multimodal, fast and ultra-sensitive imaging.

This project is directly based on the results obtained in the partner groups of the consortium that have a long and successful history of collaboration in the development of imaging techniques. This consortium can perfectly integrate the whole innovation process of this project: from the early phase of design and technological development of imaging systems to the validation on relevant biological and medical applications. The membership and the many links of the partners with the community of biophotonic imaging and imaging platforms are important assets for the validation and spreading of this technology.

The proof of concept is done. This technology is at an advanced level of technology maturation.

Financial demands in this project will cover the cost of prototyping, validation of biomedical and economic development. Two strategies are envisaged today: creating a spin-off or technology transfer to an industrial partner already identified.

Project coordinator

Monsieur Emmanuel Fort (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - DELEGATION REGIONALE ILE-DE-FRANCE SECTEUR PARIS A) – emmanuel.fort@espci.fr

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

Diderot Valorisation UNIVERSITE DE PARIS 7
ISMO CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - DELEGATION REGIONALE ILE-DE-FRANCE SECTEUR SUD
Institut Langevin CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - DELEGATION REGIONALE ILE-DE-FRANCE SECTEUR PARIS A

Help of the ANR 294,840 euros
Beginning and duration of the scientific project: January 2011 - 24 Months

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