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How to promote acceptance, uptake, and adherence to public health measures for COVID-19 prevention and control? What are the most effective ways to address the underlying drivers of fear, anxieties, rumours, stigma regarding, and how to improve public knowledge, awareness, and trust during the respo

Coronavirus disease 2019 (COVID-19) is caused by «severe acute respiratory syndrome coronavirus 2« (SARS-CoV-2). First identified in 2019 in Wuhan, China, it has since spread globally, resulting in the pandemic. While the majority of cases result in mild symptoms, some progress to severe pneumonia a

Early in the pandemic, knowledge on the socio-economic and geographical determinants of COVID19 was lacking, limiting our understanding of which populations were most likely to become infected, hospitalised and die as a result of the infection. The lockdown measures put in place to control the epide

Despite their highly strategic nature, social distancing measures are not necessarily respected, even when the health risks for each individual are scientifically proven, known and widely publicised. As some epidemiologists indicated, how individuals respond to government recommendations is at least

This project concerns the determinants of the propensity to adopt and follow the recommendations for prevention and containment in the face of the spread of Covid-19. The fundamental assumption is that this propensity is determined by the personal characteristics of the individual: one the one hand,

Since March 2020, Europe has been facing the outbreak of the new coronavirus disease 2019 (COVID-19). This highly contagious infectious disease is a viral zoonosis caused by a virus SARS-CoV-2 from the coronavirus family that emerged in Wuhan in Chine in November 2019, causing first an epidemic that

This year, the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to an unprecedented pandemic termed Covid-19 (Coronavirus disease 2019). Even as human trials of candidate vaccines are already ongoing, there is still a doubt that people can develop protective immunity

Understanding the spread of viral infectious diseases is central to informing public health decisions. Classical mathematical epidemiology primarily relies on incidence data (number of new cases per week) and contact tracing data. However, thanks to technological advances made in recent years, viral

Not even 3 months after the first news of a pneumonic infection spreading from a food market in Wuhan, China, COVID-19 pandemic has moved epicenter from China to Europe. European countries, including France, are now facing a dramatic surge of cases that is already reaching hospital capacity in some

The identification of virus-virus and virus-host protein-protein interactions is a determinant element for the understanding of the mechanisms of replication and viral transmission. The knowledge of the molecular details of these protein interactions is a prerequisite for the discovery of new therap

Since Covid-19 was first discovered in China and the WHO confirmed its human-to-human transmission, the French population has been kept informed by the media regarding the progression of the epidemy ‘til its arrival and development in France. Messages on the nature of individual prevention measures

COFUNERAIRE : building a collective answer to the funerary challenges generated by the COVID-19 pandemic The Covid-19 pandemic generates an unprecedented sanitary and social crisis. Numerous individuals are at the present time mobilized to respond to this crisis, among them actors of the funerary

The world is currently facing a pandemic of a new emerging virus from the coronavirus family named COVID-19. Detection of infected patients is crucial to break the epidemic situation. As a consequence it is essential to diagnose fast and in large number populations to sort rapidly those who are infe

Severe Acute Respiratory syndrome (SARS) is an alarming emerging infectious disease caused by coronavirus (CoV). The current COVID-19 pandemic, which originated in the Wuhan region of China, is caused by a novel coronavirus, SARS-CoV2 which is more infectious than the 2003 SARS-CoV and which has led

Following the emergence and global spread of a new coronavirus called SARS-CoV-2, there is an urgent need to explore various aspects of this new disease, including its mode of transmission, virus-host interactions and immune response, diagnosis and therapy. This collaborative project leverages the c

Naturally hosted in wild animals such as bats, betacoronaviruses (beta-CoVs) are responsible for severe and fatal human respiratory infections. Data and knowledge on animal reservoir, but also knowledge on cultural, sociological and ecological factors driving beta-CoVs spread to humans and emergence

Given the overcrowding in hospital services, the management of the health crisis linked to the SARS-CoV-2 epidemic relies in particular on the Territorial Professional Health Communities, which include doctors, nurses and physiotherapists. The challenge of caring for patients in a health system desc

In order to assist city caregivers for the management of persons suspect of or affected by COVID-19 in the Nouvelle-Aquitaine region, we have built a device composed of a call and mailing platform to answer practical questions, a web application to survey patients at home associated with a platform

The COVID-19 epidemic that emerged in China in December 2019 has spread pandemically around the world. At this time, France has recorded 16,689 confirmed cases of SARS-CoV2 and 614 deaths. In the Occitania region, 86 patients are hospitalized in intensive care units for severe pulmonary disease. In

The COVID-19 epidemic is spreading massively. This virus being new, the questions of diagnosis, prognosis, choice of treatment and pathophysiology are open. The aim is to generate standardized, real-time transcriptome data from whole blood of COVID patients, looking for diagnostic, prognostic and p

Therapeutic options in response to the SARS-Cov-2 outbreak are urgently needed and existing one are still limited. Facing pandemic development, actual strategy has been to repurpose some existing antiviral drugs used against respiratory diseases (SARS-Cov-1, MERS, Influenza) or chronic diseases (HIV

The COVID-19 pandemic is deeply destabilizing countries and their organizations, particularly in the healthcare field. Likewise, the usual ethical standards in the medical field are being disrupted. Such disruption causes anxiety or disarray among healthcare professionals, patients and their familie

The lockdown instituted by the government in March 2020 has affected the role of social actors involved with exiled people. Many associations have been alerted to the situations experienced by individuals in precarious situations. As researchers involved in the associative field in Rennes, we wonde

This project aims to analyse the representations, perceptions, attitudes and behaviours related to Covid-19 through the prism of Chinese migration in France. Some of them - medical experts, journalists, association leaders, researchers - are, as of January 2020, actively involved in the organization

Patients hospitalized for COVID-19 may need intensive care (e.g. mechanical ventilation) during hospitalization. Some risk factors are already known (e.g. sex, comorbidities, initial clinical presentation inflammatory cytokines), but better targeting of such patients is still needed, at least becaus

Context: In December 2019, a novel coronavirus outbreak was documented in Wuhan, Hubei Province, China. Over the first 6 weeks of the new decade, this novel coronavirus, known as SARS-CoV-2, has spread from China to 20 other countries and WHO recently characterized Covid-19 as a pandemic. To overcom

Current outbreak of SARS-CoV-2 virus and its social, health and economic impact put forward the need for i) potentially generic protection system that can be applied to both surfaces and persons to limit/eliminate transmission during the exponential phase of the outbreaks; ii) development of predict

The general proposal aims at investigating the representations, attitudes and reactions of public opinion in a context of the COVID-19 epidemic through a variety of countries differently exposed to the coronavirus. Contrary to conventional research projects, REPEAT has been conceived to be implement

Starting late December 2019, the emergence of an uncharacterized pathogen appeared from the city of Wuhan, China. Since then, the identified CoViD-19 virus propagated worldwide, infecting tens of thousands of humans and killing thousands. The countries suffering the most from the infectious disease

In late December 2019, a new disease named COVID-19 (COronaVirus Infectious Disease 2019), due to a new Betacoronavirus, the SARS-CoV-2, was notified in Wuhan, China. WHO declares “A public health emergency of international concern” on January 30th, 2020. A few weeks later, the virus has spread in m

Our consortium of French and Chinese social anthropologists will investigate the impact of the Covid-19 crisis on the regulation of wetmarkets in central China. Based on our expertise in the anthropology of human-animal relations in various societies and in the ethnography of the reconstruction of d

COVID-19 has emerged in December 2019 in Wuhan, China, caused by a novel RNA virus: SARS-CoV-2. As of March 22 2020, ~300,000 cases of COVID-19 and nearly 12,000 deaths (fatality rate ~4%) have been reported in the world. The high proportion of cases requiring respiratory assistance in intensive car

The goal of this proposal is not to find a vaccine, it isn’t to find a treatment either. The goal of this proposal is to learn how to deal with an epidemic in the absence of vaccines and treatment. In such circumstances, the only lever that is left for policy makers is to act on citizens’ behavior.

This proposal aims at questioning the mobilization of the military in the fight against the coronavirus, designated as an "invisible enemy". The objective of the project is twofold. On the one hand, it analyzes the decision-making process within the political institutions of the State and the Army

This project belongs to the priority “Ethics -Human and Social Sciences” and the topic “Representations, perceptions, attitudes, behavior relative to the epidemic”. Context. To stop the current coronavirus pandemic, the governments of most developed countries are implementing drastic measures to

Respiratory masks are individual protection devices of high strategic value of national and international stakes in the fight against viral bacterial and fungial diseases. Classical respiratory masks used for the protection of civil population and medical staff are adapted for efficiently filtrate a

Analyses of the health crises which have occurred in recent decades showed that they were also social, economic and political crises which were notably fed by uncertainties about actual severity of the risk, health consequences to be feared, duration of the crisis, or reactions of the population. Pu

Numerous epidemic models have been implemented to study epidemic spread in time and space. Most are of compartment type [REFS]. The increase of computational speed over the last decades make it possible to implement and study sophisticated models by massive computer simulations that can then be cal

Beginning in December 2019, a novel coronavirus, designated SARS-CoV-2, has caused an international outbreak of respiratory illness termed Covid-19, requiring for a small proportion of patients, admission to Intensive Care Unit (ICU). However, despite the urgent needs of therapeutic guidelines, litt

The ultimate aim of this project is to provide simulations of the risk of nosocomial spread of SARS-Cov2 in French hospitals as quickly as possible (within a few weeks). We will use investigation method, analysis and simulation tools derived from research works carried out in the field of multidrug

COVID-19 is an acute respiratory disease caused by novel coronavirus SARS-CoV-2 also known as 2019-nCoV. On March 11, 2020, the World Health Organization (WHO) characterized COVID-19 as a pandemic. The disease is spreading worldwide. The World Health Organization has declared a global health emergen

COMESCOV complements the AEC2-France project funded by REACTing. It is part of two axes of the ANR call: human and social dimensions of the response; preventive measures in health care settings and in population. The objective is to document and analyse the social experience of sanitary measures (

The purpose of the MASKOVID project is to examine, from a social science point of view, the contribution of masks as a tool to combat the virus, among other possible means. Covid-19 poses an unprecedented challenge in terms of health protection: in the absence of a vaccine and specific drugs, other

Pandemic SARS-CoV-2 (COVID-19) respiratory infection is responsible for more than 4,000 deaths, mainly (67%) secondary to acute respiratory distress syndromes (ARDS) (Yang 2020) . ARDS is usually associated with a mortality of around 40% (Gilbert 2018), but this rate reaches 61% in patients infected

Background: The current COVID-19 outbreak could be devastating among dependent elderly people housed in nursing homes and long-term care facilities (NHLTFs) given the intensity of contacts (between residents and between residents and staff) and the difficulty to identify infection in this elderly po

The SAPRIS project aims to conduct a general population survey to understand the main epidemiological and social issues of the SARS-CoV2 epidemic. In particular, the understanding and implementation of prevention measures, the perception of risk for oneself and in general, the prevalence of symptoms

Since December 2019, the novel coronavirus (SRAS-COV2, causing an emerging infectious disease called COVID-19) has spread quickly worldwide. As of Mar 16th 2020, 165 000 cases and 6 500 deaths have been reported over 146 countries (WHO data). In Europe, Italy, Spain, France and Germany are currently

Antiviral strategies targeting replication machineries have proven their efficacy, with as gold example the cure of HCV patients and to a lesser extent the HIV treatments that control viral load. One of the prerequisites is a detailed knowledge of the structure and function of the multi-protein repl

The major role of human genetic variability in immunity to infection is now well established, in particular for viral infections. We have identified a number of monogenic inborn errors of immunity (IEIs) underlying life-threatening viral diseases, such as herpes simplex virus encephalitis, fulminant

Beyond biomedical research, it is imperative that the SARS-CoV-2 pandemic be studied in terms of its impact on health systems, including health professionals. Indeed, all public health efforts currently being implemented in France and elsewhere are aimed at reducing the burden of COVID-19 on fragile

Research on COVID-19 is currently hampered by the delayed availability and lack of diversity of small rodent models of SARS-CoV-2 infection. Wildtype mice are poorly susceptible to this virus due to the sequence divergence between the mouse and the human in the ACE2 gene which acts as the virus rece

ECOVID-19 aims to provide a comparative cost-effectiveness analysis (CEA) of public policies undertaken in real-life conditions during the Covid-19 epidemic in France. We will compare three main measures: i) confinement measures ii) testing with a specific focus on undocumented infections iii) remin

Background: The emerging SARS (Severe Acute Respiratory Syndrome)-CoV (Corona virus)-2 is a novel airborne coronavirus threatening public health that is currently spreading worldwide causing the severe respiratory syndrome known as COVID-19 1, for which no treatment is yet available. One of the rel

Whether host genetic determinants influence the susceptibility to and severity of COVID-19 is unknown. Cytotoxic T cells recognize virus-infected cells after presentation of short viral peptides within the binding groove of HLA class 1 (HLA-1) molecules. NK cells also recognize virus-infected cells

As of March 23rd 2020, the COVID-19 outbreak is affecting > 340,000 people worldwide, carrying a mortality rate ranging from 1/1000 in some countries but reaching several % in others. This variability may result from the rate of detection which differs in these countries, but it also relies on the

AM-COV-Path aims at the development of a non-human primate model of the SArS-CoV-2 infection and disease. We will use this model to study the mechanisms of transmission and pathogenesis, focusing on dynamics of viral dissemination, the associated tissue damages in the respiratory tract and at sites

How can we find the right words and arguments to convince the population to adopt behaviors that are healthful, not on an individual basis but in the name of the general interest? The CIESCO project aims to understand the conditions of reception and acceptance of speeches made by government offici

Rationale. Recommended infection control precautions for COVID-19 include the use surgical mask in most care situations, for limiting the contamination of mucosa by large droplets. However, several invasive respiratory procedures can generate aerosols of small particles, requiring the use of a N95 o

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originat-ed in Wuhan, China, has become pandemic and a major concern all over the world. By March 22, 2020, this virus has a?ected more than 320,000 people worldwide and caused more than 14,000 deaths. Despite the un

Whereas the pandemic due do Covid-19 continues to spread, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Severe Acute Respiratory Distress Syndrome in 30% of patients with a 30%-60% mortality rate for those requiring hospitalization in an intensive care unit. The main physio

Since December 2019, a new coronavirus, SARS-CoV-2, has been identified in the city of Wuhan in China. By 22 March 2020, the virus had spread to all continents, causing 294 110 confirmed cases and 12 944 deaths worldwide. The detection and spread of this emerging respiratory pathogen are accompanied

Since the outbreak of Ebola, in 2014, MMN-ESPCI and CIBU-PASTEUR have worked together to develop a portable test, dedicated to the detection of nucleic acids of pathogens, viruses and bacteria, exploiting the latest developments of microfluidic paper technology and molecular diagnostics. Together, w

The epidemic due to the Sars-CoV2 virus is spreading in France with an increasing number of affected patients. The medical and paramedical staff of the front-line departments for the care of patients infected with Covid-19 are potentially exposed to the risk of occupational contamination due to the

On 03-11-2020, the WHO declared a pandemic, due to an emerging betacoronavirus identified in China on 12-31-2019, named SARS-CoV-2. Responsible of the COVID19 syndrome, this virus induces a pathology which clinical spectrum ranges from asymptomatic cases to the occurrence of ARDS. Molecular biology

Faced with health crises, the elderly are among the most at risk, as the 2003 heat wave in French has shown, excess mortality related to age being particularly marked in people living alone or in nursing homes. Even though the COVID-19 epidemic is far from over, it is more than likely that the elder

The propagation of the SARS-COV2 in France has completely overloaded health facilities until producing an unprecedented confinement on our territory. In order to mitigate as much as possible sanitary and economic consequences, it is mandatory to try anticipating the level of local transmission and t

French blood donor population contribution to SARS-CoV-2 studies: epidemiology, natural history, human & social sciences and therapy Acronym: COVIDonneur This project addresses the topics "Epidemiological and translational studies" and "Ethics - Human and social sciences associated with

This research proposal falls within the field of ethics, understood as a transversal and interdisciplinary reflection aimed at clarifying the "moral motives" of our actions (values, norms, purposes, consequences). The particularity of our approach is to place this reflection as close as possible to

Coronavirus disease (COVID-19) is an infectious disease that primarily targets the human respiratory system and is caused by a novel virus denoted ‘Severe Acute Respiratory Syndrome coronavirus 2’ (SARS-CoV-2). The immune response to SARS-CoV-2 is the primary cause of the lung pathology and associat

The ARISE project will produce an air analyser equipped with detection capabilities for the ubiquitous monitoring of airborne SARS-CoV-2 pathogens to monitor confined environments. COVID-19 is a recently occurring disease caused by the SARS-CoV-2 coronavirus. Its spreading is rapid and hard to cont

COVID-19 has reached a pandemic scale in a few months and is devastating the heath systems of many nations. Knowledge of the virus is still parcelar, but asymptomatic but infectious carriers appear to be driving the explosive growth of the disease. In absence of a vaccine, the best way to manage the

Optimizing home treatment for patients with COVID-19 and risk factors for aggravation could reduce hospitals' workload and improve individual outcomes. This is one of the biggest challenges to be met in the coming weeks. We propose a trial to compare possible drugs for this indication to the curren

Lysosomotropic agents for the treatment of COVID-19: azithromycin, chloroquine and hydroxychloroquine Phase II clinical trials have led to the preliminary conclusion that chloroquine, hydroxychloroquine and azithromycin may reduce the viral load in patients with COVID-19, spurring the launch of m

In order to address the health crisis around the SARS-CoV-2 infection, there is a growing need and demand for diagnostic tools that are complementary and different from the RT-PCR currently in use. Moreover, in view of the worldwide demand for testing, it is important to have new tools and tests pro

To tackle the spread of the Covid-19 epidemic, governments have imposed new and unprecedented rules of social life, which have disrupted everyday practices and may have profound effects on different segments of the population. We will assess the social effects of the epidemic and confinement in Fran

The W-covid project consists in designing an automated, simple, economical and robust system allowing the diagnosis of covid-19 at home or in a medical service, by an non-specialist operator, using a saliva swab. The system consists of three main parts: - a consumable pre-filled tube for saliva

The novel coronavirus SARS-CoV-2 has recently emerged as a human pathogen in China’s Hubei province, causing severe respiratory illness and pneumonia. According to the World Health Organization (WHO) on March 17th, 2020, there have been over 180,000 cases globally, leading to at least 7,500 deaths.

Current knowledge of the natural history of COVID-19 is mainly based on the description of hospitalized cases, but, to our best knowledge, no data has been reported from the general population. In agreement with the COVID-19 research priorities identified by the WHO, and with the research topics tar

The recent outbreak of pneumonia-inducing and potentially lethal COVID-19 has become a major world-wide public health issue with dramatic societal and economical consequences. The SARS-CoV-2-inducing COVID-19 belongs to the Betacoronavirus family, and is close to the previously emerged SARS-CoV and

An exceptional effort to constitute a biobank of blood samples from patients with COVID-19, admitted to the hospital wards of the Public Hospitals in Paris (Assistance Publique-Hôpitaux de Paris: AP-HP), will be undertaken as an emergency measure, starting on March 23, 2020 with all regulatory and e

The occurrence of an infectious disease epidemic, such as the one caused by the Covid-19 virus can be a source not only of morbidity and mortality, but also considerable disruptions in people's lives, causing psychological, social and economic damage. In terms of mental health, research based on rec