COVID-19 - Coronavirus disease 2019

Acoustic and Optic bioSensors for label-free CoVId-19 fast diagnosis – AcOstoVie

Submission summary

The world is currently facing a pandemic of a new emerging virus from the coronavirus family named COVID-19. Detection of infected patients is crucial to break the epidemic situation. As a consequence it is essential to diagnose fast and in large number populations to sort rapidly those who are infected. Diagnosis of COVID-19 is carried out by a molecular biology approach consisting in the detection of the COVID-19 RNA genome by a quantitative RT-PCR approach. This strategy is efficient but is time consuming and needs a trained medical staff in a dedicated laboratory. Here we propose a new strategy based on physics technologies :acoustic and optical. AcOstoVIe project aims to prototype a label-free COVID-19 diagnosis device, based by on 2 biosensors on a same quartz substrate. A Quartz Crystal Microbalance (QCM) and an optical reflexion – existing technologies already tested for ebola virus diagnosis – will be integrated in a sytem to detect COVID-19 (i) RNA genome (ii) viral particles and (iii) serology of infected patients. Compared to existing technologies, AcOstoVIe project will provide the valuable advantages : (i) point-of-care diagnosis, (ii) faster (< 30 min), (iii) friendly user (no trained medical staff), (iv) nomad without restriction of dedicated laboratory localization, (v) double check detection, (vi) partly reusable. From the Proof of Concept delivered after T0+12, the system will be next challenged with infectious and non-infectious sample fluids issued from collaborations with medical infrastructures and virology laboratories. The final compact system will be next co-design with practitioners.

Project coordination

Pascal LEBLANC (Institut Neuromyogène)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

INMG Institut Neuromyogène
L2n-UTT Lumière, nanomatériaux, nanotechnologies - CNRS ERL7004

Help of the ANR 199,680 euros
Beginning and duration of the scientific project: April 2020 - 18 Months

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