COVID-19 - Coronavirus disease 2019

Quantification and spread of SARS-CoV-2 in the surrounding air and fomites of patients suffering from COVID-19 – Cacao

Submission summary

Rationale. Recommended infection control precautions for COVID-19 include the use surgical mask in most care situations, for limiting the contamination of mucosa by large droplets. However, several invasive respiratory procedures can generate aerosols of small particles, requiring the use of a N95 or FFP2 mask. High flow nasal oxygen (HFNO) is increasingly used in place of conventional oxygen mask (COM) for the care of patients with de novo respiratory failure, but its high gas flow raises concerns about aerosolization of small infectious particles and spread of infection.
Project. We aim at studying the environmental contamination by SARS-CoV-2 in relation to oxygen therapy modality and patients’ room characteristics. We will take the opportunity of the recently funded COVIDICUS clinical trial, in which 600 patients will be included to study the efficacy of various oxygen therapy modalities and of corticosteroids in severe COVID-19 patients.
Methods. Environmental samples, including air and surfaces from the COVID-19 patients’ room, will be collected at 6 occasions over the 24 first hours using a BioSampler or VIVAS device (for air) and Dacron swabs pre-moistened for surfaces. Virological analyses will be performed in order to detect and quantify the presence of the SARS-CoV-2, and evaluate its infectivity by viral culture. Specific analytical methods will be developed. The contamination of the patients’ room will be studied using mixed effect statistical modeling of the data.
Expected results. This project will provide important data about the viral risk for the healthcare workers, and therefore for other hospitalized patients, that will be useful to compare in other settings. By comparing data from several settings and ICU practices will be of valuable help to identify the best practice for preventing the expansion of SARS-CoV-2 in the hospital and staff protection.
Consortium. This project will be conducted in partnership with internationally renowned French research teams. The project will be led by L. Bouadma (Bichat intensive Care Unit, University of Paris & APHP) and A. Mekontso Dessap (Henri Mondor intensive Care Unit, Paris-East University & APHP). The Principal Investigator of the COVIDICUS trial, which has already been funded by the Ministry of Health and APHP and will begin shortly, is JF. Timsit (Bichat intensive Care Unit, University of Paris & APHP). The environmental sampling will be performed by Jean-Christophe Lucet (Bichat Infection Control Unit, University of Paris & APHP), the virological analysis of the samples will be led by B. Visseaux (Bichat Virology Laboratory, University of Paris & APHP). Statistical analysis will be led by C. Burdet (Bichat Epidemiology, Biostatistics and Clinical Research Department, University of Paris & APHP).

Project coordination

Lila Bouadma (Infection, anti-microbien, modélisation, évolution)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

IAME Infection, anti-microbien, modélisation, évolution

Help of the ANR 183,185 euros
Beginning and duration of the scientific project: March 2020 - 12 Months

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