Search

Strategies that aim at extending the duration of anti-VEGF effects (gene therapy, small antibodies, implantable reservoir) will not benefit to all patients because VEGF is not the only molecular target in AMD31. MR-A-AMD aims at validating that MR pathway is a novel and pertinent target to be tested

Besides the classical Richardson form of the disease, Progressive Supranuclear Palsy (PSP) may have several other presentations defining PSP variants, which can be difficult to differentiate clinically from Parkinson’s disease (PD), especially at the early stage of the disease. In this project we pr

We propose to investigate the properties of a serum-based diagnostic strategy, which uses a selective array sensing rather than specific, mimicking olfaction mechanism: each sensing element of the array interacts differentially with serum components, generating a unique pattern tied back to the seru

Cytotoxic anticancer drugs cannot be administered by the subcutaneous (SC) route due to the risk of inducing tissue irritation/necrosis. This is a loss for patient intake as SC is a simpler and faster route of administration than the traditional intravenous (IV) injection. Indeed, SC is commonly use

Ten percent of the European population is on long-term statin therapy. Statins reduce major vascular events and vascular mortality in a large number of individuals. However, the efficacy and safety of this therapy is uncertain with elderly people, who often present co-morbidities and potential drug

During the last twenty years, the extremely high flux of photons generated by 3rd generation synchrotrons, has enabled the development of novel irradiation strategies holding great promises for innovative radiotherapy. In particular, the possibility to split weakly diverging synchrotron-generated X-

Recently, thanks to 3D printed technology, we developed a customized calcium phosphate implant presenting interesting properties for bone repair. The morbidity of the commonly used procedure would be relieve thanks to the development of a customized biomaterials. Tridimensional (3D) printing is cons

We designed the translational RESPIRE project to test the hypotheses that: 1) sevoflurane could be beneficial in ARDS by decreasing RAGE-mediated lung epithelial permeability (mechanistic in vitro, in vivo, in silico studies and analysis of human samples from patients enrolled in a multicenter clini

There is currently no tool to monitor the progression of fibrosis and the effectiveness of these treatments. The objectives of this project are: 1/ to evaluate the therapeutic efficacy of blocking hypoxia signaling via inhibition of HIF1a, HSP90 and LRP1 in experimental fibrosis, 2/ develop and eva

Using saturated transposon (Tn) mutagenesis and high-throughput sequencing (TnSeq), a powerful tool to investigate host-pathogen interactions, we will fill-in-the-gaps in our knowledge about the contribution to overall fitness of the multitude of genes in E. coli K1 needed to cause neonatal meningit

Charcot-Marie-Tooth disease (CMT) is the most common hereditary peripheral neuropathy in humans (1 in 2500 people). More than 90 CMT genes are known to date. For more than 40% of them, premature stop codon (PTC) mutations are responsible for the disease. These PTC mutations lead to the production of

Automated personalised prediction of the risk of TdP in cLQTS or diLQTS patients, can improve the accuracy of the physician's assessment and reduce the risk of cardiac events. This project aims to develop such a tool using artificial intelligence, which is rapidly reaching medical practice. Deep lea

The dIAg-EM project has two objectives, both related to the development of elementary imaging by LIBS (Laser-Induced Breakdown Spectroscopy) for the analysis of medical samples: 1) Develop an artificial intelligence algorithm (based on deep artificial neural networks) capable of performing, in real

The disease modifying treatments that are currently under assessment in manifest patients (HD patients) defined by a score equal to or greater than 5 at the motor evaluation of the Unified Huntington’s Rating Scale (UHDRS). Most trials use as an endpoint this universally accepted scale (which quanti

Despite much work by a large number of research teams, the ex vivo manufacture of clinically-grade, transplantable human hematopoietic stem cells (HSCs) has not yet been achieved. Two teams have recently published the conversion of adult endothelial cells or human induced pluripotent stem cells (hiP

CADASIL is an adult-onset, dominantly inherited neurovascular disorder caused by NOTCH3 mutations. It is characterized by a variable spectrum of symptoms, even within families, including recurrent subcortical infarctions, dementia, and less frequently, migraine and psychiatric symptoms. We have rece

The objective of the research project "Neurovita-ALS" is to study the therapeutic potential of a new molecule, Neurovita, in the treatment of amyotrophic lateral sclerosis (ALS). It brings together, in a translational approach, two academic laboratories, Institut Pasteur (IP) and Institut du Cerveau

Alzheimer’s disease (AD) consists of a continuum from an asymptomatic preclinical form to the disease objectivated by cognitive and memory tests. Differential diagnosis is difficult during the asymptomatic preclinical phase of the pathology. Alzheimer's disease is defined by the association of a pro

Human brainstem, a complex brain structure, is the main relay centre for afferent and efferent connections between the cerebral cortex, cerebellum and spinal cord. Due to its spatial localization, size and tissue characteristics, brainstem poses particular challenges for MRI, with potential major cl

Impaired splenic function (hyposplenism) affects more than 0.4% of the French population, half of them splenectomised, portends a serious risk of complications, including severe infections, thromboembolism and leukemia. While many splenectomised patients are fully asplenic, loss of function is parti

Brain-Computer Interfaces hold great promise for motor-impaired patients, but non-invasive approaches using EEG still suffer from unreliable and unstable performance both for rehabilitation in stroke patients, and for restoring control in quadriplegics. Clearly, a fine-grained individual strategy is

Parkinson’s disease is characterized by the dopamine denervation leading to motor symptoms, and spreading of misfolded alpha-synuclein in the brain. However, the serotoninergic system is also affected and has been linked to non-motor symptoms that may precede the motor phase of the disease. The pres

phase I/II. Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease, characterized by muscular paralysis due to the loss of motoneurons in the spinal cord, motor cortex and the brainstem. The majority of cases are sporadic (90%) and familial forms are associated with different gen

Inflammatory bowel diseases (IBDs) result from exacerbated immune activation in the intestinal mucosa. T cells participate to the immune homeostasis of the intestine but are also implicated in the inflammatory response during the disease. We study the repertoire of T cell receptors to identify, char

Extreme prematurity is constantly increasing according to the World Health Organization. Currently, in France, about 13,000 very premature infants are born at less than 32 weeks of gestation each year. This situation creates a real public health problem because the increase in the survival of very p

Context- Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative motoneuron (MN) disease. ALS is considered as a protein misfolding disorder, accompanied by neuroinflammation that accelerates MN cell death and disease progression. To date, the absence of both biomarker discovery and key cel

Obesity, which has a prevalence at 15% in France, is a major public health concern. Altered glycemic control and irritable bowel syndrome (IBS) are frequently observed in obese patients and lead to reduce the quality of life. In the last decades, the role of gut microbiota and intestinal permeabilit

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia occurring in 1% of the general population, associated with significant morbidity and mortality and has become an important public health problem worldwide. Current treatments based on anti-arrhythmic drugs and ablation procedur

Crohn’s disease (CD) leads to high disability altering daily life. CD incidence has dramatically increased worldwide, and Europe has the highest prevalence rate. Clinical benefits to cytokines blockade have remained limited to a subset of patients. Up to 40% of patients never respond to anti-TNF. We

Amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) are fatal neurodegenerative diseases characterized by accumulations of TDP-43 and FUS, two proteins selectively binding to RNAs enriched in GU, transcribed from CA-rich sequences. Our recent results show CA-repeats, enriched in b

As In Vitro Fertilization (IVF) success rate is limited, it is crucial to improve IVF outcome by gaining better knowledge on embryo quality assessment. As morphology is poorly predictive of implantation, the identification of non-invasive markers of embryo quality is a relevant strategy, such as com

Improving the understanding of the biology underpinning abnormal brain development and connectivity in Autism Spectrum Disorders (ASD) is a major challenge in translational research in psychiatry. The integration of studies across different levels of analysis (genetic, functional, clinical, brain im

Background: A main objective of Partner 1 is to improve mechanistic insight and care of monogenic intestinal disorders. A new syndrome combining congenital diarrhea, cholestasis, deafness and bone fragility was recently ascribed to mutations in UNC45A, a member of the UCS protein family (UNC-45/ C

Hidradenitis Suppurativa (HS; OMIM #142690) is a chronic recurrent inflammatory skin disease affecting hair follicles (HF) leading to draining sinuses, painful skin abscesses and disfiguring scars. HS is a common disease, with a point prevalence of 4% in Europe. HS is an orphan and frequent disease

Although membranous nephropathy (MN) is a rare auto-immune disease (incidence, 1/100 000), it is the commonest cause of nephrotic syndrome in adults. Since 2009, the identification of the podocyte antigen M-type phospholipase A2 receptor 1 (PLA2R), has induced major changes in the standard of care t

ß-thalassemias and sickle cell disease (SCD) are caused by mutations in the ß-globin gene (HBB) that result in defective synthesis (ß-thalassemias) or production of an abnormal variant (SCD) of hemoglobin. Currently, the only curative option is allogeneic transplantation of hematopoietic stem cells

Complement system is a major part of innate immunity and plays a role in cell homeostasis and mounting of adaptative immune response. Complement overactivation is increasingly implicated in pathophysiology of numerous kidney diseases. Among them, C3 glomerulopathy (C3G) is the prototype of disease m

Focal cortical dysplasia (FCD) are epileptogenic malformations of cortical development leading to drug resistant epilepsy in children. Surgical treatment is the gold standard to treat these patients and offers the unprecedented opportunity to better understand the mechanisms of epilepsy exvivo. I ha

In France, about 5000 new people with a primary malignant brain tumor are diagnosed each year. The most common primary tumors are gliomas, originating from glial cells (astrocytomas and oligodendrogliomas). Low-grade gliomas are mildly aggressive, but they often evolve into a more malignant form.