T cell in Inflammatory Bowel Diseases – T-IBD

Inflammatory bowel diseases (IBDs) result from exacerbated immune activation in the intestinal mucosa. T cells participate to the immune homeostasis of the intestine but are also implicated in the inflammatory response during the disease. We study the repertoire of T cell receptors to identify, characterize and localize disease-associated T cell clones in the mucosa of IBD patients. In both healthy and inflammatory mucosa, T cells interact with numerous cellular partners, such as epithelial cells. To study this lympho-epithelial crosstalk in human, we culture organoid from normal or inflammatory tissues and analyze their interactions with autologous T cells isolated from the same organ. Our aim is to determine and modulate the pathways involved in these interactions in order to reduce tissular damage in the context of IBD.