CE17 - Recherche translationnelle en santé

Development and Validation of brainstem-dedicated multimodal imaging to explore tissue microstructure (DEVINET) – DEVINET

Submission summary

Human brainstem, a complex brain structure, is the main relay centre for afferent and efferent connections between the cerebral cortex, cerebellum and spinal cord. Due to its spatial localization, size and tissue characteristics, brainstem poses particular challenges for MRI, with potential major clinical impact. The present project is designed to define a clinically practical method that could be implemented in clinical trials. The originality of our proposal is to develop a brainstem protocol combining data acquisition and data processing. We identified 3 challenges to overcome: 1) to develop harmonized high spatial resolution multimodal brainstem-dedicated MRI sequences 2) to determine relationships between MR and tissue parameters 3) to develop brainstem-dedicated multi-imaging tool as an open-access data analysis software. Tools developed through DEVINET project will be validated by investigating patients with brainstem damages, to confirm their clinical pertinence.

Project coordination

Patrice Péran (TOULOUSE NEURO IMAGING CENTER)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

TONIC TOULOUSE NEURO IMAGING CENTER
CHU Toulouse - DRI CHU de Toulouse - Direction de la Recherche et de l'Innovation
CRMBM Centre de résonance magnétique biologique et médicale
CHU Bordeaux - DRCI CHU de Bordeaux - Direction de la Recherche Clinique et de l'Innovation
IHAP Interactions hôtes-agents pathogènes

Help of the ANR 349,543 euros
Beginning and duration of the scientific project: January 2021 - 48 Months

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