CE17 - Recherche translationnelle en santé

Impairment of the serotonergic system during the prodromal phase of Parkinson’s disease – ProdomalPD

Submission summary

Parkinson’s disease is characterized by the dopamine denervation leading to motor symptoms, and spreading of misfolded alpha-synuclein in the brain. However, the serotoninergic system is also affected and has been linked to non-motor symptoms that may precede the motor phase of the disease. The present project aims to further investigate the impairment of the serotoninergic system at the prodromal stage of the disease in carriers of alpha-synuclein gene mutations (rare disease), and, in parallel, in an animal model of prodromal serotoninergic injury. We will investigate by state of the art of PET imaging and deep clinical and behavioral assessment the relationships between impairment of pre and post-synaptic serotonergic markers and the presence and severity of non-motor symptoms. The better understanding of the pathophysiological mechanisms taking place during the prodromal phase of the disease may lead to new therapeutic options to reduce these non-motor symptoms.

Project coordination

Véronique Sgambato (Institut des sciences cognitives Marc Jeannerod)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

ISCMJ Institut des sciences cognitives Marc Jeannerod
INSERM INSERM DRVI

Help of the ANR 689,847 euros
Beginning and duration of the scientific project: January 2021 - 48 Months

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