CE17 - Recherche translationnelle en santé

Dissecting mononuclear phagocytes heterogeneity in Crohn’s disease – CDMNP

Submission summary

Crohn’s disease (CD) leads to high disability altering daily life. CD incidence has dramatically increased worldwide, and Europe has the highest prevalence rate. Clinical benefits to cytokines blockade have remained limited to a subset of patients. Up to 40% of patients never respond to anti-TNF. We recently identified a GIMATS (IgG-plasma cells, inflammatory mononuclear phagocytes (inf.MNP), activated T and stromal cells) module enriched in anti-TNF resistant patient intestines, likely driven by inf.MNP. The cellular and molecular diversity, location, interactions, and molecular programs of MNP differentiation remain largely unexplored in human intestine. We propose to apply high-dimensional single cell approaches to in-depth exploration of MNP transcriptomic and epigenetic heterogeneity in CD. We hypothesize that characterizing the programs driving inf.MNP differentiation and interactions with fibroblasts will offer new therapeutic opportunities tailored to anti-TNF non-responders.

Project coordination

JEROME MARTIN (Centre de Recherche en Transplantation et Immunologie)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

CRTI Centre de Recherche en Transplantation et Immunologie

Help of the ANR 401,745 euros
Beginning and duration of the scientific project: November 2020 - 48 Months

Useful links

Explorez notre base de projets financés

 

 

ANR makes available its datasets on funded projects, click here to find more.

Sign up for the latest news:
Subscribe to our newsletter