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New strategies for decoding cyclophilin biological functions – CYP-TAC
Cyclophilins are a family of proteins that catalyzes the cis/trans isomerization of peptide bonds at proline residues, which facilitates protein folding. CypA, the most abundant cyclophilin isoform, has been described as a key player in viral infection for viruses such as HCV, dengue virus, coronavi
Development of Succinate-based analogues and formulations against SARS-CoV-2 and influenza viruses-induced respiratory infections – SuccesS
The emergence of pandemic respiratory viruses is a major concern. Those viruses include coronaviruses such as SARS-CoV-2 and influenza A viruses (IAV). There are currently no efficient drugs against coronaviruses and the efficacy of anti-IAV drugs is disputed. Vaccination should constitute the most
Bioinspired scaffolds to fight human coronaviruses – CoroNat2
The COVID-19 pandemic caused by SARS-CoV-2 has highlighted the urgent need to identify antiviral compounds against human coronaviruses (HCoV). The multidisciplinary CoroNat2 project involves 4 complementary teams, each with pre-existing technical expertise in virology, phytochemistry, chemistry and
Systemic and mucosal immune response variation during SARS-CoV-2 infection and recovery – CoVarImm
Coronavirus disease (COVID-19) is an infectious disease that primarily targets the human respiratory system and is caused by a novel virus denoted ‘Severe Acute Respiratory Syndrome coronavirus 2’ (SARS-CoV-2). The immune response to SARS-CoV-2 is the primary cause of the lung pathology and associat
Inhibition of SARS-Cov2-S - ACE2 interaction AS A THERAPEUTIC TARGET – ACE2-S-Cov
Coronavirus disease 2019 (COVID-19), which is caused by the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become pandemic, in the absence of an approved drug treatment or prophylactic vaccine. The virus surface spike protein (S), which mediates coronavirus ent
Determinants of SARS-CoV-2 infectivity in a cohort of children and their parents. – PED-COVID_Infect
COVID-19 represents an unprecedented world-wide challenge due to the transmissibility of the virus, its impact on morbidity and mortality, the uncertainty regarding the development of long-term immunity, and the current paucity of efficient therapeutic options. Understanding the kinetics of shedding
Characterization of the role of betacoronavirus M protein in viral assembly – coronem
Coronaviruses are positive-stranded RNA, enveloped viruses. The lipidic envelope contains 3 viral proteins with the membrane protein (M) being the most abundant component and the driving force in viral assembly. The main objective of this project is to better understand the morphogenesis of MERS-CoV
SARS RNA Synthesis and Processing Activities – SARS-RNA-SPA
Unraveling the SARS-CoV replication mechanisms are essential to the development of new antiviral strategies. We decipher how the enzymatic activities present in the replication transcription complex are interconnected to ensure the replication of the viral genome and their addition of a cap structur
Mechanisms of Action of anti-SARS-CoV-2 – MACoVA
Antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) contribute to vaccine efficacy and are used as therapy against Coronavirus Disease 2019 (COVID-19). They act by neutralizing viral replication, but also by recruiting immune effector mechanisms. These so-called non-neutr
Role of proinflammatory cytokines, PML nuclear bodies, and the HIRA histone chaperone complex in epigenetic changes associated to SARS-CoV-2 infection – CHROMACoV
Cytokine storm is a hallmark of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which causes coronavirus disease 2019 (COVID-19). As a consequence some patients could develop severe inflammatory diseases some of which leading to cardiac failure. Tumor Necrosis Factor alpha (T