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New strategies for decoding cyclophilin biological functions – CYP-TAC
infection for viruses such as HCV, dengue virus, coronaviruses and HIV-1. One hypothesis is that CypA plays [...] decipher the role of CypA in viral infection for coronaviruses, by combining biochemical assays with two c [...] worked together in the field of cyclophilins and coronavirus. The Cyp-TAC consortium has 3 objectives (1)
Development of Succinate-based analogues and formulations against SARS-CoV-2 and influenza viruses-induced respiratory infections – SuccesS
viruses is a major concern. Those viruses include coronaviruses such as SARS-CoV-2 and influenza A viruses (IAV) [...] There are currently no efficient drugs against coronaviruses and the efficacy of anti-IAV drugs is disputed [...] impairs vaccine protection. Besides, previous coronaviruses crises showed that poorly neutralizing antibodies
Bioinspired scaffolds to fight human coronaviruses – CoroNat2
identify antiviral compounds against human coronaviruses (HCoV). The multidisciplinary CoroNat2 project [...] synthetic analogue, all active against the coronaviruses SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E [...] molecules with common structural features and pan-coronavirus activity. Preliminary results suggest that these
Inhibition of SARS-Cov2-S - ACE2 interaction AS A THERAPEUTIC TARGET – ACE2-S-Cov
Coronavirus disease 2019 (COVID-19), which is caused by the recently discovered severe acute respiratory [...] respiratory syndrome coronavirus 2 (SARS-CoV-2), has become pandemic, in the absence of an approved drug treatment [...] virus surface spike protein (S), which mediates coronavirus entry into the cell, is an attractive target
Systemic and mucosal immune response variation during SARS-CoV-2 infection and recovery – CoVarImm
Coronavirus disease (COVID-19) is an infectious disease that primarily targets the human respiratory [...] virus denoted ‘Severe Acute Respiratory Syndrome coronavirus 2’ (SARS-CoV-2). The immune response to SARS-CoV-2 [...] Nevertheless, immune responsiveness to this novel coronavirus appears quite variable in humans as indicated
Determinants of SARS-CoV-2 infectivity in a cohort of children and their parents. – PED-COVID_Infect
shedding of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), and the duration of viral infectivity [...] prior immunity to SARS-CoV-2 or to seasonal coronaviruses on the duration of SARS-CoV-2 infectivity warrants [...] (ii) pre-existing antibodies towards seasonal coronaviruses; (iii) co-infections with specific respiratory
Characterization of the role of betacoronavirus M protein in viral assembly – coronem
Coronaviruses are positive-stranded RNA, enveloped viruses. The lipidic envelope contains 3 viral proteins [...] at identifying cellular factors involved in coronavirus assembly and how the M protein may recruit these
SARS RNA Synthesis and Processing Activities – SARS-RNA-SPA
We deciphered regulation mechanisms of the polymerase activity in the replication / transcription complex and we have identified a proofreading mechanism unique in RNA virus world. In addition, we characterize the viral enzymes involved in the synthesis of the cap structure present at the 5 ' end of mRNA. This structure is needed to translate RNA into viral proteins and limit their recognition by innate immunity mechanisms.
Role of proinflammatory cytokines, PML nuclear bodies, and the HIRA histone chaperone complex in epigenetic changes associated to SARS-CoV-2 infection – CHROMACoV
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which causes coronavirus disease 2019 (COVID-19)
Mechanisms of Action of anti-SARS-CoV-2 – MACoVA
Antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) contribute to vaccine efficacy [...] efficacy and are used as therapy against Coronavirus Disease 2019 (COVID-19). They act by neutralizing viral
