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Crystalline product assisted by intensified CO2 process – CYPRES
The solid state of drugs is a major issue in the pharmaceutical field. On the one hand, the isolation of new crystalline forms of an active ingredient (polymorphs, hydrates) with specific properties can have a significant impact on the marketing of the drug concerned, including the publication of ne
GLobal UsE of Boron Catalysts for Adhesives – GLUE-BOCA
The challenge is to find the right borinic acid derivative that will catalyze the formation of polyesters, polyamides and polysiloxanes. Each compound must meet the criteria of effectiveness, stability and toxicity in order to be incorporated into the final formulation. Catalysts have been identifie
Hyperactive catalytic species in the liquid phase from nanoparticles or immobilized molecular species – HYPERCAT
The Suzuki-Miyaura reaction (Suzuki) suffers from serious drawbacks for a wide industrial application. The first is the fate of the catalysts. The Suzuki reaction indeed operates in the presence of Pd, in the form of molecular complexes, colloidal or supported Pd nanoparticles. Health, environmental
Constrained oligonucleotides-based Catalysts – CoolCat
The objectives of the project consist in the joint use: - of constrained oligonucleotides on a peptide platform in a single topology, - metal complexes, - tetrads of synthetic guanines, for asymmetric catalysis reactions, in particular sulfoxidation. On the Grenoble site (UGA), doctoral student
Frontiers in tetrazine derivatives functionalization: meta and para selective C-H activation – FIT-Fun
In the last few years s-tetrazines have been the object of considerable interest in various fields, which spread out from energetic materials to biomedicine. Despite this significant extent of applications, the synthetic preparation modes of functionalized s-tetrazine remain very limited. They mainl
Hierarchical CHAbazite core-shell catalysts for Reduction of NOx and N2O – CHARO
The project will address some of the main pollutants produced by stationary and mobile sources, such as nitrogen oxides (NOx) and nitrous oxide (N2O). Their abatement will be explored via the ubiquitous selective catalytic reduction reaction using ammonia (NH3-SCR) as a selected model reaction. The
Design of Photosensitizers based on a Singlet Oxygen Reservoir for Antibacterial Applications – CaROS
The objectives of the project are: 1) Development of a new synthetic route towards phenalenone-derived photosensitizers and covalent attachement of a unit able to capture, store and release singlet oxygen. 2) Study of the properties of photosensitizers and applications in antibacterial photodynami
Gas-liquid plasma micro-reactors for future chemistry – PLAS4CHEM
The long term objective of the project is to develop a new tool able to perform chemical reactions of industrial interest without catalysts and without solvents, using reactive species (radicals, excited neutrals, metastables, photons…) generated in gas phase by plasma discharges at room temperature
A strategy for the popularization of Si and C based nanochemistry – Si-POP
Currently, carbon and silicon nanomaterials possess a wide range of application toward biomedicine and optoelectronics, but they can only be afforded by physical methods using sophisticated and expensive laboratory equipment (elaborate machines) at harsh conditions. Therefore, the high cost and synt
Sialic acids engineering as a strategy for alternative antibacterial discovery – NEURAPROBE
The main objectives of the NEURAPROBE project are: (1) to develop new labeling tools and study incorporation of sialic acids using the bioorthogonal chemical reporter strategy in pathogenic bacteria, compared to human cells, as well as cellular infection models, and (2) to detect key differences
Intelligent end-of-pipe catalytic systems suited for alternative fuels – SMARTCAT
The SmartCat project will tackle main issues related to the development of innovative and cost-efficient end-of-pipe technologies, in connection with the use of alternative fuels less harmful in terms of atmospheric pollution and the reduction of critical materials of strategic importance such as PG
Light-activated Nickel catalysts – LightNing
We target the development of structurally-simple photoreducible Ni(II) precatalysts, with the aim that such precatalyts will represent valuable tools for applications in key reactions catalysed by low-valent Ni species. The main objectives are : 1- Design / synthesis of photoreducible Ni(II) comp
Fluorinated Ligands Approach for the Inhibition of Rotamases – F-LAIR
The incorporation of fluorine atoms into biomolecules has gained a considerable interest as they are known to modulate the properties of pharmaceuticals. Fluorine can often favorably and predictably alter the biophysical and chemical properties, such as lipophilicity, chemical stability, metabolic
A novel mechanically enhanced bioleaching process – BIOMECALIX
In the context of hydrometallurgical processes dedicated to the recovery of metals, the leaching step consists of dissolving solid particles (ores, waste to be recycled) in an aqueous phase. With the aim of improving yields, a wiser use of resources and reducing effluents, the BIOMECALIX project aim
Molecular modelling of the organic solvent nanofiltration process: a better understanding for a better use – MANIAC
MANIAC is a fundamental research program that aims at removing this bottleneck by rationalizing the molecular mechanisms governing membrane separations in non-aqueous media thanks to molecular simulations carried out with both polymer membranes and polymer/MOF mixed matrix membranes. Atomistic model
Chiral Iodanes for Asymmetric Carbon–Carbon Bond Construction – IODOCHEM
The chemistry of hypervalent iodine compounds (iodanes) has experienced an impressive development since the early 1990s. Major current and competing research efforts focus on the design of chiral iodane structures for asymmetric synthesis and organoiodo-catalyzed versions thereof. While remarkable p
Imine Photochemistry: Photoinduced radical reactions of imines – IMPHOCHEM
Investigation of photochemcial reactions of imines (mechanistic investigations, stereochemistry, application to organic synthesis) Design and the building of a new in-house microphotoreactor operating in this UV-B domain. Performing and optimization of photochemical reactions of imines in this re
Confinement of peptide sequences in Porous Macroligand for Asymmetric Catalysis – PoMAC
This is a major challenge for pharmaceutics. Indeed, chiral molecules represent 56% of the drugs marketed, and although enantiomers have the same chemical structure, they usually exhibit different physiological properties, making their separation crucial. To prepare enantiopure molecules, conventio
Protease-like Oligonucleotides, Functionalization and Catalysis – PrOLIFiC
This project aims at the rational design of functionalized oligonucleotides (FuON) covalently modified to expand their catalytic repertoire towards biomimetic reactions to give access to protease-like DNA catalysts. Those nucleic mimics would be designed to perform the hydrolysis of the amide bond w
N-HetAryl-Iminoiodanes: new Nitrene precursors for novel Organic Fluorophores – HINOF
The objectives of this project are dual. First, we wish to develop a new synthetic route to obtain nitrenes from simple amines under mild reaction conditions. HINOF aims to exploit iminoiodinane intermediates, in association or not with metal catalysts. The generalization of this approach will be st
Synergistic Catalysis: a new tool for Cycloaddition Reactions – CycloSyn
The first objective was to study the reactivity of free oxyallylcations, formed in situ from a-tosyloxyketones, towards numerous 1,3-heterodipoles. A more ambitious task consists in investigating the behaviour of transition-metal stabilized oxy- and azaallyl cations. Using this strategy, the diatere
Chiral Lewis Bases – Pivotal Species for Asymmetric FLP- and Lewis Acid-Catalysis – CLABcat
Despite the long-standing and still spectacular achievements of transition metals as catalysts, they exhibit some drawbacks whose importance could grow in the next decades: 1) transition metals are expensive materials; 2) They are an issue in the pharmaceutical industry because of their toxicity —wi
Catalysts with Metal-Ligand Cooperation for Sustainable Energy – CatEngy
The objective of this fundamental research project is to develop new and efficient homogeneous organometallic catalysts with metal-ligand cooperation for challenging transformations targeting sustainable sources of energy. Lately, Partner 1 prepared unprecedented robust air-stable tethered oxocycloh
New Prospects for the Catalytic Asymmetric Construction of Fluorinated Carbon Centers – FLUORASYM
By developing original and unprecedented catalytic tools to access chiral fluorinated building blocks, the FLUORASYM project will open new avenues toward the discovery of pharmaceuticals or agrochemicals, an important challenge from an industrial point of view. Indeed, the lack of methodologies to p
Au-based multimetallic nanoparticles embedded in zeolite nanoboxes for NO direct decomposition in excess O2 – DECOMPNOx
to be published to be published Decomposition du NO sur des nanoalliages 1. “Comment on “Direct Decomposition of NOx over TiO2 Supported Transition Metal Oxides at Low Temperatures””, J. Schnee, L. Delannoy, G. Costentin, F. Meunier, and C. Thomas, Industrial & Engineering Chemistry Research, 2020,
Catalytic Scaffolds based on Amyloid aggregates – CatSAmy
Catalysis is widely accepted as one of the leading factors for promoting sustainable development. Although high selectivities have been achieved by tailored made catalysts, the synthesis of the latter is often obliterating the sustainability of the overall process. Our project aims at tackling this
New Opportunities for Peptide Synthesis – NOPS
Amides are among the most important functional groups in organic chemistry. In addition of their crucial role to sustain life, they are also present in several natural products, materials and are also one of the most prolific moieties in modern drug-like compounds. Classical amide syntheses involve
Stereoselective transition metal-catalyzed hydrometallation of polarized C=C bonds – HydroMet
With the HydroMet project, we would like to investigate further the transition metal-catalyzed hydrometallation of polarized triple C=C bonds and develop efficient methodologies to make this reaction regio- and stereoselective. Usually, hydrometallation suffers from very low selectivity or is totall
Protein-crosslinked DNA nanogels as enzymatic nanoreactors – ActiveGEL
This project aims the development of a new class of easily functionalizable dynamic DNA-protein nanogels with controlled size and density. These DNA nanogels will be produced by crosslinking long multi-biotinylated DNA via streptavidin-biotin interactions. Using streptavidin conjugates will allow us
Association of microwave technology to reactive polymer systems without solvent in the molten state – MOMix
MOMix is a multidisciplinary project involving specialized laboratories and firms in thermal modelling, microwaves, processing and polymer chemistry. The project ambition a technological breakdown in the field of reactive processing implementing polymers in the molten state and under high shears.
Heterogeneous Cascade oxidations catalyzed by mesoporous artificial enzymes – NikAGARA
In the context of green chemistry, cascade catalytic reactions appear as ideal solutions for industry. Combining strategies from biocatalysis to chemocatalysis, the Ni(k)AGARA project aims at experimentally demonstrating the concept of cascade catalysis in cristallo on oxidative transformations of a
Hidden Catalysis with Strong Lewis Acids – HICAT
Organic synthesis greatly relies on strong Lewis acid-catalyzed processes and the use of such compounds raises questions about the nature of the active species. Strong Lewis acids have indeed the potential to mediate the formation of protons in various ways in the reaction medium (hidden proton cata
Access to C-glycosides by directed metal-catalyzed C-H functionalization at the anomeric position. – SuCH_Fun
Although sugars play a crucial role in many biological processes, their uses in therapeutics remain limited due to their low stability. That’s why organic chemists are constantly pushed to develop new access to original analogues. In particular, replacement of natural anomeric link by C-C mimics (C-
Mass spectrometry for the reactivity analysis of copper-based catalytic oxidation of organic substrates. – SUPEROXO-MS
Nature has developped metalloenzymes that are responsible for selective oxygenation of organic substrates by O2 with remarkable performances under mild conditions. Among those, copper monooxygenases catalyse a two-electron oxidation process of an organic substrate based on a Cu(II)-Cu(I) redox pro
Membrane processes in ScCO2 medium for economical supercritical processes – MemScCO2
Green chemistry principles lead to non-solvent or green solvent processes among which CO2 in sub or supercritical state (ScCO2) has been considered as an excellent choice for its modulable transport properties as density, viscosity diffusivity of compounds in ScCO2 and its good solvent power for non
On demand Selective Functionalization of Sugar C(sp3)–H bonds Using a Transient Directing Group (TDG) strategy – SelF-SuCHi
The development of innovative, atom-efficient and selective processes for C-C bond formation in the field of C-glycosides synthesis is of paramount importance, in particular regarding the constant increase of C-glycoside drugs being developed. In this context, C(sp3)-H bond functionalization of su
Organotitanium (II): a versatile reagent for a rapid access to [5-7] bicycles and highly functionalized systems – TVA
In this proposal, several reactivities of versatile, inexpensive and readily available titanium (II) reagent (?2-propene)-Ti(OiPr)2 will be examined. At first, its strong affinity towards alkynes will be exploited in unprecedented carbocyclization as well as cyclocarbonylation reactions to respectiv
A small ring into the bigger picture – Benz
This research program centers on the development of new methodologies in organic chemistry and their applications towards the synthesis of complex molecular scaffolds. Our approach relies on synthetic innovation and is driven by the importance of step economy towards the construction of molecular di
Reprogramming metalloenzyme reactivity for abiological catalysis – Abiozyme
As part of the transition to a sustainable bioeconomy, it is expected that the chemical industry will increasingly rely on biotechnologies such as biocatalysis and synthetic biology for the production of compounds such as pharmaceuticals, agrochemicals, flavors and fragrances. However, to reach thei
A luminogenic real-time detection system for monitoring enzymatic manufacturing of oligonucleotides – LuminoManufacOligo
In drug discovery, new modalities are chemical entities (e.g., peptides, oligonucleotides, carbohydrates, …) of intermediate size between small molecule therapeutics and biologics (i.e., proteins, antibodies). They aim at combining the efficient cell intake of small molecules with biologics' ability
Ligand-driven light-switching of Single Molecule Magnets – Light-Up-SMM
Circuits integrating molecular-scale components may ultimately allow the replacement of silicon-based electronics by high speed systems with low energy consumption. Because of the prominent use of magnetization-based information storage technologies in our daily life, Single-Molecule-Magnets (SMM)
Selenium And Fluorine Associated: the wedding of two stars (SAFA) – SAFA
To answer to the growing interests for new molecules in various applications fields (life science, materials), the development of innovative functional groups is more and more required. Selenium and fluorine have been identified as atoms playing a central role in the modulation of the properties of
Amplification of Enantioselectivity in Organocatalysis: Fast Catalyst Screening, Developments & Synthetic Applications – AMPLI
The Ampli project aims at addressing the two major following issues in modern enantioselective catalysis : 1/ How to quickly select a good catalyst among a library of available molecules, hence minimizing optimisation experimental studies which can turn to be tedious ? 2/ How, starting from th
Ketenes [3+2] cycloadditions – KetFlo
Developing new reactivities is crucial for the progress of Organic Chemistry, in order to develop faster, selective and sustainable access to always more complex molecules, both for research and industry. In the KetFlo project, we will study the unprecedented (3+2) cycloadditions between ketenes and
Left Beta-Helix peptides for the design of Artificial Metallo-enzymes – LeBHel-AMzymes
In order to reduce the energy consumption of chemical industry, as well as its impact on environment, new catalysts — based on earth abundant elements — are necessary. Catalysts made by anchoring a metal center in a protein scaffold are called artificial metallo-enzymes. The combination of catalytic
Luminescent biAryl Phospholes for Peptide-Receptors Tracking – LAPPRET
The development of fluorescence techniques is continually renewed by the instruments progresses, the discovery of new fluorophores and labelling methods. In a recent past, much efforts were dedicated to the development of optoelectronic devices, optical imaging for diagnosis and guided-treatment bas
Low Loading Asymmetric Catalysis with Helical Chiral Oligoureas – HCO_for_LLAC
Organocatalysis is a rapidly expanding methodology enabling challenging chemical transformations to be performed in the broad context of sustainable chemistry (metal-free procedures, catalyst recycling…) in line with Challenge 3, CS07 of the ANR Work Program 2018. Despite major achievements, organoc