On demand Selective Functionalization of Sugar C(sp3)–H bonds Using a Transient Directing Group (TDG) strategy – SelF-SuCHi

The development of innovative, atom-efficient and selective processes for C-C bond formation in the field of C-glycosides synthesis
is of paramount importance, in particular regarding the constant increase of C-glycoside drugs being developed. In this context, C(sp3)-H
bond functionalization of sugars offers a unique opportunity to access to these compounds of synthetic interest from readily
available starting materials. The Self-SuCHi ANR proposal starts from an exciting preliminary results to explore a novel approach
to functionalize sugars and propose the use of a transient directing group (TDG) for activation and functionalization/quaternization of
inert C(sp3)-H bonds. We wish to explore the whole possibilities of functionalization of all five positions of the sugar nucleus (either
the anomeric position or the others C(sp3)-H (2-5) sugars positions). Indeed, DFT computations will be used to understand the
reaction mechanisms and the origins of regio- and stereoselectivity.