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Emotional Facial and Linguistics feedback, and Post-Traumatic Stress States – REFLETS
The theory of peripheral emotional feedback – that our emotional experiences are under the retroactive influence of our own expressions – has been an ongoing subject of debate in psychology since William James. On the one hand, the fact that putting on a smile or a frown may have an implicit, automa
Development and validation of a clinical device for blood-brain barrier opening with transcranial focused ultrasound – 3BOPUS
The combined use of focused ultrasound and microbubbles is known to be able to strongly enhance drug delivery to the brain, with safety already proved in many animal models. In human, several promising clinical trials are ongoing but used devices are either invasive or suboptimal for BBB opening. 3B
Non-invasive ultrasound based therapy of human calcified aortic stenosis – VALVOSOFT
The goal of this 30-month project is to produce the first proof of concept of this therapeutic approach on humans (First In Man). To achieve objective, a fully functional clinical prototype will be developed, based on real-time echocardiographic guidance and innovative ultrasonic monitoring tools. T
Decision Support System for Individualized Prescription of mHealth Devices and Apps – ApiAppS
The objective of the ApiAppS project is to identify, explore and remove existing scientific obstacles so that general practitioners (GPs) can use a system to be of help in the prescription of mHealth apps/devices adapted to the patient's profile. This system will be interoperable with the informatio
Virtual Patient Simulation Tool for Training Health and Social Care Staff Working with People with Alzheimer's Disease or Related dementia – VIRTUALZ
Taking care of the growing population of people with dementia worldwide requires specifically-trained healthcare professionals.Their training should not only involve foundational knowledge but also skills to communicate effectively with people with dementia, cope with care challenges and guarantee p
Communication, Literacy, Education, Accessibility, Readability – CLEAR
The CLEAR project proposes innovative methods allowing the creation of linguistic resources and software dedicated to the simplification of medical texts written in French. The software is expected to be the mediator in the communication between patients and medical professionals. The project addres
ROBOTIC BIOPSY OF THE UTERUS STANDARDIZED TECHNIQUE – ROBUST
Several studies and a FDA report clearly demonstrate the critical importance of a diagnosis tool allowing to differentiate benign and malignant tumours before a uterine minimally-invasive operation. The problem is, among the numerous diagnostic tools used by clinicians to evaluate women with tumour,
Shape fitted MRI bra coil – Bracoil
Magnetic Resonance Imaging (MRI) is the technique of reference to replace ionizing X-ray mammography for screening of breast cancer for women at risk. However, conventional MR mammography has several drawbacks in terms of specificity due to low temporal resolution, patient comfort and adaptation to
Integrated magnetic probes for neuronal current imaging. – NeuroTMR
Neuronal activity is based on charge transfers, which create electric potentials and ionic currents. These currents are generating magnetic fields which are detectable. These low-frequency magnetic fields pass through biological tissues without significant distortion, thus enabling efficient, remote
Atherosclerosis and Myocardial Imaging by Spectral Photon Counting CT and Hybrid Nanoparticles – ATHERSPECTRALCT
The specific objectives of the ATHERSPECTRAL-CT project are: • To develop and perform, with already clinically available Gd nanosized particles a very high spatial resolution non-invasive angiography • To perform quantitative myocardial perfusion evaluation using clinically available Gd nanosized
Design of a transesophageal HIFU probe for the treatment of cardiac arrhythmias – CHORUS
Technological developments - Improve the HIFU transducer technology in order to deliver more surface energy faster and ensure MR-compatibility - Reduce the probe dimensions to facilitate clinical transfer - Allow multiplane ultrasound imaging from the esophagus - Design a 2D matrix for multipl
From soft tissue's fibrous Microstructure to Voice biomechanics : towards the material design of a new biomimetic oscillator – MicroVoice
The study of human vocal production is complex because it involves many coupled phenomena, e.g. acoustic, aerodynamic and biomechanical phenomena. Today, compared to the knowledge acquired on the aero-acoustic characterization of human voice, the histological and biomechanical specificities of the v
Laser Breathalyzer – ETHYLAS
The ETHYLAS project aims at the development of an innovative breathalyzer using a laser source. This sensor will be based on an optical technique using new generation light source, emitting a wide spectral range in the mid-infrared domain. Optical gas sensors are already a part of our modern society
Electrostimulation of wound healing: toward a more effective therapy – WHEEL
Chronic wounds are a serious public health issue. In 2014, 3.6 million patients presented chronic wounds in France. This number is increasing each year because of population aging and the increasing prevalence of chronic disease such as diabetes and obesity. Classical options for wound treatments ar
Computer assisted fetal monitoring – SurFAO
To monitor the well-being of a fetus or for a clinical diagnosis, a challenge is to extract a fetal electrocardiogram (fECG) signal of high quality from a limited number of non-invasive sensors on the maternal abdomen. The SurFAO project aims to enhance the current clinical routines for two actual c
Smart Organic Electroactive Textiles for health monitoring – OrgTex
Today, novel and exciting wearable technologies are available in the market providing non-intrusive health monitoring capabilities in fashionable way. Designing of functional devices that can assist physicians in monitoring the healing process of a patient will facilitate medical surveys and help
Injectable and haemostatic hydrogel for guiding and reconstruction of deep wounds – GELIHPARBAL
The goal of the GELIHPARBAL project is to create injectable hydrogels that can be used as an emergency solution for deep and jagged wounds, to decrease bleeding immediate threat while improving muscle repair and functional skin healing. A new avenue of research, based on the development of biomat
Functional ultrasonography for intraosseous blood circulation assessment – FUIBCA
Intraosseous blood circulation is thought to have a key role in bone growth and remodeling, in fracture healing and in the development of bone disorders. However it is rarely considered in the clinical practice because of the absence of a suitable technique for its in vivo evaluation in humans. Inad
MR Thermometry for radiofrequency ablation in atria and ventricles, a key point for efficacy and safety – CARTLOVE
Catheter ablation is the cornerstone of curative treatment for arrhythmia however the success rate of this procedure for complex arrhythmia like ventricular tachycardia and atrial fibrillation, requiring a complete electrical isolation, is currently limited by the lack of visualization of the lesion
ROI tomography and dose reduction – ROIdore
In computerized tomography (CT), the density function, or more precisely the attenuation function, of a patient is obtained by reconstruction algorithms applied to radiological projections measured by a scanner. From these radiological projections, it is possible to calculate integrals of the patien
MicroRobot-assisted Cholesteatoma Surgery – muRoCS
Cholesteatoma is a skin growth that occurs in an abnormal location in the middle ear. It is usually due to repeated infection. It was estimated that one new case per 10,000 citizens occurs each year. Over time, cholesteatoma expands in the middle ear, filling in the empty cavity around the ossicles
Electro-deposited Calcium-phosphate coatings for biomedical applications – DECaP
Every year, more than 200 000 orthopaedic prostheses (knee, hip) and a huge (but unknown) number of dental implants are implanted in France. For an optimal efficiency, these implants have to be well integrated in bone. To favour osseointegration, dental implants rely on modification of their surfac
Fast Single-Pixel Biomedical Imaging – Armoni
Recent advances in signal processing have made it possible to design new digital imaging systems. Single-pixel imaging is a new paradigm that enables two-dimensional imaging from a point detector. It has raised increasing attention because it allows high-performance optical imaging systems (e.g., hy
Anatomical Models to study Aerosol DElivery to the lUngS for obstructive diseases – AMADEUS
Aerosol therapy consists in the administration of aerosolized drugs and is considered to be one of the cornerstones in the management and treatment of chronic respiratory diseases. Some of the most common are chronic obstructive pulmonary disease (COPD) in adults and bronchiolitis in children. Vario
Development and assessment of spectral CT for early detection of osteoarthritis – SALTO
OA is a severe public health problem, which concerns a large percentage of patients and is estimated to increase on the next 10 years. It is associated with pains, problems in quality of life and disability. The relevance of diagnostic imaging for assessing the integrity of the joint is well recogni
Adaptive, subject-specific Vagus Nerve Stimulation – AdaptVNS
Vagus nerve stimulation (VNS) is an approved clinical therapy for medically refractory epilepsy and depression. More recently, VNS has been proposed as a promising therapeutic approach for other pathologies such as heart failure, cardiac arrhythmia, inflammation and auto-immune diseases. One common
Microsystem based test device for the Global assessment of primary HaemOSTasis with flowing whole blood – GHOST
Von Willebrand disease (vWD) is a blood disorder in which blood does not clot properly. vWD occurs with equal frequency among men and women, affecting up to 1% of the general population. Between 2012 and 2016, more than 14600 men, women, and children were seen at hemophilia treatment centers for tre
Combining connected functionalities for the acquisition of health data aimed towards a multimodal approach – ACCORDS
The ACCORDS project aims at solving three issues related to Internet of Things (IoT). The first one consists in developing a software library to ensure interoperability with a set of sensors while putting aside the sensor model to focus on data. The current lack of interoperability restricts the num