DS04 - Vie, santé et bien-être

Development and assessment of spectral CT for early detection of osteoarthritis – SALTO

Submission summary

OA is a severe public health problem, which concerns a large percentage of patients and is estimated to increase on the next 10 years. It is associated with pains, problems in quality of life and disability. The relevance of diagnostic imaging for assessing the integrity of the joint is well recognized, especially for early detection of Osteoarthritis (OA). Conventional radiography is still the standard imaging diagnostic tool, which is sensitive to late OA. However, there are not current methods for detecting early OA with sufficiently high resolution and image quality to visualize at the same time the internal structure of the bone, meniscus and details of cartilage. A new generation of X-RayCT systems called Spectral CT (SP-CT) should provide energy-dependent information, which translates into material decomposition capabilities allowing a better quantification of the different constituents of tissue. However, such systems are currently only available at the stage of prototypes and must be thoroughly assessed and validated. The main objectives are to investigate the ability of SP-CT based on photon counting detectors and associated to new data processing methods to characterize cartilage and meniscus integrity and to investigate possible biomarkers that could improve diagnosis of OA, especially devoted to early detection of OA. To achieve these goals the following sub-objectives will be addressed: 1) Verify the theoretical feasibility of SP-CT to image soft tissue of joints (cartilage, meniscus, and ligaments) and to establish the best requirements for contrast and signal-to-noise ratio (by using computer simulated studies). 2) Validate the energy resolution of SP-CT images by using energy-dependent gold-standard images from the synchrotron radiation. 3) Enhance image quality of SP-CT by testing state-of-the art reconstruction algorithms. 4) Test the feasibility of SP-CT for OA diagnosis in comparison with histopathology scorings of the meniscus and cartilage. 6) In case of image of sufficient quality, investigate possible biomarkers for detection of early OA. This project will combine experimentations on a unique SP-CT prototype and development of image processing methods for SP-CT reconstruction and analysis as well as specific expertise on OA imaging.
The strategy developed in this project has a high potential to contribute to the development of the new generations of SP-CT devices and their evaluation in the diagnosis of OA,

Project coordination

Francoise PEYRIN (Centre de Recherche en Acquisition et Traitement d'Images pour la Santé)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

CREATIS - CNRS Centre de Recherche en Acquisition et Traitement d'Images pour la Santé
B2OA Laboratoire de Bioingénierie et Biomécanique Ostéo-articulaires

Help of the ANR 340,311 euros
Beginning and duration of the scientific project: - 42 Months

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