DS04 - Vie, santé et bien-être

Injectable and haemostatic hydrogel for guiding and reconstruction of deep wounds – GELIHPARBAL

Submission summary

The goal of the GELIHPARBAL project is to create injectable hydrogels that can be used as an emergency solution for deep and jagged wounds, to decrease bleeding immediate threat while improving muscle repair and functional skin healing.

A new avenue of research, based on the development of biomaterials, has appeared in recent years as an alternative to classical tissue reconstruction approaches, such as grafts. Their aim is to provide a scaffold that will activate or guide cellular responses to enhance or trigger tissue regeneration. Nevertheless, if these biomaterials are trying to reproduce specific properties of the extracellular matrix (notably rigidity) to influence cell fate, elasticity has seldom been considered so far.
Concomitantly, the possibility to provide haemostatic competences to these biomaterials, through induction of the blood clotting cascade by prothrombotic molecules and through filling and compression of the wound, opens new possibilities to control haemorrhagic risks.

The GELIHPARBAL project therefore aims to develop an innovative therapeutic approach for deep wounds based on the use of injectable porous elasto-mimetic hydrogels that, through their intrinsic properties, allow concomitantly (1) the haemostatic filling of deep wounds, while (2) providing a specific guidance of muscle and skin repair.

A major innovation will be the injectable formulation of porous elastic hydrogels that can compressively fill and conform accurately to the wound shape; and allow wound healing cells colonization while reinforcing their regenerative properties through mechanic and structural properties. The elasto-mimetic porous hydrogels developed during a previous ANR project (DHERMIC, ANR-11-TECS-016) will serve as technological basis for the development of the injectable formulations. The coordinating laboratory (Laboratory of tissue biology and therapeutic engineering, LBTI) has indeed reached the "biological" proof of concept of these approaches by validating the efficacy of the hydrogels in forming reconstructed skin equivalents and enhancing skin wound healing in vivo. This project therefore falls within the design and creation of innovative, bioinspired biodegradable and bioactive materials.

To reach this ambitious goal, the consortium formed by three institutional partners (CNRS and INSERM) possesses the required competences and expertise’s to develop the biomaterials (LBTI), to finely analyse their mechanical, rheological (RMeS) and biological properties (INMG), and to study and evaluate the improvement of tissue healing and the resulting functionality gain (LBTI)

The scientific program is divided in 3 scientific work packages (chemistry/biomaterials, mechanobiology and in vivo) and an administrative WP.
They have for goal to 1) design elasto-mimetic haemostatic injectable porous hydrogels of large mechanical versatility; 2) Determine the mechanical and structural properties of porous matrices most effective in guiding proliferation and differentiation of muscle stem cells and in inducing muscle regeneration; 3) develop injectable porous hydrogels that can simultaneously promote muscle and skin regeneration.
The administrative task is dedicated to the project and intellectual property management.

Project coordination

Jerome SOHIER (Biologie Tissulaire et Ingénierie Thérapeutique)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

INMG - CNRS Institut Neuromyogène
LBTI- CNRS Biologie Tissulaire et Ingénierie Thérapeutique
UNantes RMeS, UMR_S 1229 Université de Nantes, RMeS (Regenerative Medicine and Skeleton), UMR_S 1229 (ancien LIOAD, U791)

Help of the ANR 467,553 euros
Beginning and duration of the scientific project: - 36 Months

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