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New strategies for decoding cyclophilin biological functions
infection for viruses such as HCV, dengue virus, coronaviruses and HIV-1. One hypothesis is that CypA plays [...] decipher the role of CypA in viral infection for coronaviruses, by combining biochemical assays with two c [...] worked together in the field of cyclophilins and coronavirus. The Cyp-TAC consortium has 3 objectives (1)
Development of Succinate-based analogues and formulations against SARS-CoV-2 and influenza viruses-induced respiratory infections
viruses is a major concern. Those viruses include coronaviruses such as SARS-CoV-2 and influenza A viruses (IAV) [...] There are currently no efficient drugs against coronaviruses and the efficacy of anti-IAV drugs is disputed [...] impairs vaccine protection. Besides, previous coronaviruses crises showed that poorly neutralizing antibodies
Systemic and mucosal immune response variation during SARS-CoV-2 infection and recovery
Coronavirus disease (COVID-19) is an infectious disease that primarily targets the human respiratory [...] virus denoted ‘Severe Acute Respiratory Syndrome coronavirus 2’ (SARS-CoV-2). The immune response to SARS-CoV-2 [...] Nevertheless, immune responsiveness to this novel coronavirus appears quite variable in humans as indicated
Inhibition of SARS-Cov2-S - ACE2 interaction AS A THERAPEUTIC TARGET
Coronavirus disease 2019 (COVID-19), which is caused by the recently discovered severe acute respiratory [...] respiratory syndrome coronavirus 2 (SARS-CoV-2), has become pandemic, in the absence of an approved drug treatment [...] virus surface spike protein (S), which mediates coronavirus entry into the cell, is an attractive target
Determinants of SARS-CoV-2 infectivity in a cohort of children and their parents.
shedding of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), and the duration of viral infectivity [...] prior immunity to SARS-CoV-2 or to seasonal coronaviruses on the duration of SARS-CoV-2 infectivity warrants [...] (ii) pre-existing antibodies towards seasonal coronaviruses; (iii) co-infections with specific respiratory
Characterization of the role of betacoronavirus M protein in viral assembly
Coronaviruses are positive-stranded RNA, enveloped viruses. The lipidic envelope contains 3 viral proteins [...] at identifying cellular factors involved in coronavirus assembly and how the M protein may recruit these
SARS RNA Synthesis and Processing Activities
We deciphered regulation mechanisms of the polymerase activity in the replication / transcription complex and we have identified a proofreading mechanism unique in RNA virus world. In addition, we characterize the viral enzymes involved in the synthesis of the cap structure present at the 5 ' end of mRNA. This structure is needed to translate RNA into viral proteins and limit their recognition by innate immunity mechanisms.
Mechanisms of Action of anti-SARS-CoV-2
Antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) contribute to vaccine efficacy [...] efficacy and are used as therapy against Coronavirus Disease 2019 (COVID-19). They act by neutralizing viral
Role of proinflammatory cytokines, PML nuclear bodies, and the HIRA histone chaperone complex in epigenetic changes associated to SARS-CoV-2 infection
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which causes coronavirus disease 2019 (COVID-19)
Genome-wide CRISPR screens for drug target identification and inhibition of SARS-CoV-2 replication
y syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the current coronavirus disease 2019 [...] global economic crisis. SARS-CoV-2 is the seventh coronavirus identified as capable of infecting humans and
