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Development of Succinate-based analogues and formulations against SARS-CoV-2 and influenza viruses-induced respiratory infections – SuccesS
viruses is a major concern. Those viruses include coronaviruses such as SARS-CoV-2 and influenza A viruses (IAV) [...] There are currently no efficient drugs against coronaviruses and the efficacy of anti-IAV drugs is disputed [...] impairs vaccine protection. Besides, previous coronaviruses crises showed that poorly neutralizing antibodies
Coronavirus disease 2019 (COVID-19), which is caused by the recently discovered severe acute respiratory [...] respiratory syndrome coronavirus 2 (SARS-CoV-2), has become pandemic, in the absence of an approved drug treatment [...] virus surface spike protein (S), which mediates coronavirus entry into the cell, is an attractive target
Coronavirus disease (COVID-19) is an infectious disease that primarily targets the human respiratory [...] virus denoted ‘Severe Acute Respiratory Syndrome coronavirus 2’ (SARS-CoV-2). The immune response to SARS-CoV-2 [...] Nevertheless, immune responsiveness to this novel coronavirus appears quite variable in humans as indicated
Determinants of SARS-CoV-2 infectivity in a cohort of children and their parents. – PED-COVID_Infect
shedding of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), and the duration of viral infectivity [...] prior immunity to SARS-CoV-2 or to seasonal coronaviruses on the duration of SARS-CoV-2 infectivity warrants [...] (ii) pre-existing antibodies towards seasonal coronaviruses; (iii) co-infections with specific respiratory
Coronaviruses are positive-stranded RNA, enveloped viruses. The lipidic envelope contains 3 viral proteins [...] at identifying cellular factors involved in coronavirus assembly and how the M protein may recruit these
We deciphered regulation mechanisms of the polymerase activity in the replication / transcription complex and we have identified a proofreading mechanism unique in RNA virus world. In addition, we characterize the viral enzymes involved in the synthesis of the cap structure present at the 5 ' end of mRNA. This structure is needed to translate RNA into viral proteins and limit their recognition by innate immunity mechanisms.
Role of proinflammatory cytokines, PML nuclear bodies, and the HIRA histone chaperone complex in epigenetic changes associated to SARS-CoV-2 infection – CHROMACoV
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which causes coronavirus disease 2019 (COVID-19)
Genome-wide CRISPR screens for drug target identification and inhibition of SARS-CoV-2 replication – CRISPR-TARGET-CoV
y syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the current coronavirus disease 2019 [...] global economic crisis. SARS-CoV-2 is the seventh coronavirus identified as capable of infecting humans and
Identifying SARS-CoV-2-like and other coronaviruses able to infect humans in bats from Indochina peninsula – BAT-CoV-ASIA
objective of the project is to identify bat coronaviruses close to SARS-CoV-2 and other alpha and bet
The main goal of the NanoMERS project is the identification of specific and efficient nanomaterials derived anti-MERS-CoV agents effectively inhibiting viral entry and their in vitro and in vivo testing. The focusis on the use of carbon based nanostructures, notably modified C-dots and graphene-dots and nanoparticle formulations of poly(D, L-lactide-co-glycolide) (PLGA).