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Target Ion Source for Short-Lived Ion Production – TULIP
Speed and efficiency are of the essence and must be tweaked to first produce short-lived (tens of milliseconds) alkali RIB before moving to the ultimate goal of metallic RIB in the region of 100Sn. These target-ion sources are designed to operate in extreme environments, and rely on materials able
Additive Manufacturing Process Industrialisation – Indus-ADDI
The transition from proof of concept to industrialization of Additive Manufacturing (AM) processes is not a smooth ride. Additive manufacturing is a new process that offers significant potential in the manufacture of highly functional parts. Numerous research studies have demonstrated the functional
Carbon Aerogels Doped with NItrogen and Abundant Metals for Efficient and Sustainable Membrane Electrode Assemblies – ANIMA
The world energy demand is rapidly rising with fossil fuels meeting most of the increase and renewables seeing impressive gains. However, the intermittent production of renewables calls for the development of electrochemical energy storage and conversion systems. Water electrolysers and fuel cells a
Redox modulation of rhodium-catalyzed nitrene insertions into C(sp3)-H bonds – CHamRhOx
The direct transformation of C-H bonds into C-N bonds is an area of intense research because, as an atom-economical reaction, it makes the synthesis of complex nitrogen-containing molecules more efficient, with multiple applications in both life sciences and fine chemistry. In this context, rhodium-
A risky market? The emergence of predictive maintenance of military systems in France – PREDICT-OP
From a theoretical point of view, the study of digital data markets presents particularly important scientific challenges. Considering that the organization of market spaces always refers to a process of definition and implementation of rules by the State (Weber, 1971; Fligstein, 1990; Fligstein, 19
System Level Understanding of Zinc and Phosphate Signalling Crosstalk – PHLOWZ
A major component of cells, phosphate (Pi) is a strategic resource due to the increasing depletion of high-quality phosphate rocks. To limit its use in crop production, we need a better understanding of the factors stimulating its uptake. Plants in Pi and Zinc (Zn)-poor soils accumulate more Pi than
A therapeutic target for ischemic related injuries, application to organ transplantation – KIRI
This project aims to design a new generation of pharmacological inhibitors capable of countering the consequences of an ischemic episode. They target a protein that we have recently identified and implicated in the resistance of organs to ischemia. The clinical application is kidney transplantation.
Réunis pour Renforcer la Dynamique de Développement
Suite à la phase de structuration globale du projet effectuée en 2021, le projet a connu en 2022 des avancées notables sur les 4 thèmes : Sur le thème Inviter, attirer, briller , la dynamique de recrutement des talents scientifiques est bien ancrée. L’action « welcome package » par exemple
Mitochondrial and protease dysfunction in progeroid Cockayne syndrome cells and during age-associated processes – CS_AGE
We study the underlying mechanism of the altered pathway that we identified in CS cells, where oxidative and nitrosative stress (ROS/RNS) promotes overexpression of the HTRA3 protease, which results in the degradation of the key mitochondrial DNA polymerase POLG1 responsible for replication of the o
Innovative gene therapy breakthroughs in inherited immune disorders of the hematopoietic system
Le RHU a été remanié après son démarrage du fait du désengagement d’YPOSKESI, l’Universite´ de Zurich et Miltenyi ce qui nous a contraint à abandonner les WP1 et 2. Le projet a été recentré sur les WP3 et WP4 avec Flash Therapeutics (FTX) comme seul et unique producteu
