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Tax reforms and tax revolts in democracies – TAXREV
The design of redistributive tax policies is an evergreen in the public discourse. Research on these questions has led to a well-developed “theory of optimal taxation” with seminal contributions by Mirrlees (1971), Piketty (1997), Diamond (1998) and Saez (2001; 2002). These contributions have in com
New diagnostic and therapeutic solutions to cotrol bleeding complications during the use of mechanical circulatory support devices
Le développement d'un "bio-stéthoscope quantitatif" basé sur l'analyse du VWF clivé au point-of-care (POC) est en cours. Le développement d'un test basé sur les nanocorps pour quantifier la dégradation du VWF a été effectué. Deux nanocorps permettant la quantification du VWF ont été sélectionnés. Le
Wearable Nano-Opto-electro-mechanic Systems – SNOW
Motivation: Health and fitness wearables present mobile solutions for ICT in public wellbeing by providing personal remote control and clinical intervention through telemedicine networks. Due to their noninvasive and continuous vital sign monitoring, wearables are incorporated in several studies t
Artificial-Intelligence-based Methods for Nanobody Design – ANDES
ANDES aims at developing and experimentally validating new computational methods for nanobody design, with a large spectrum of applications (therapies, diagnosis…) in order to have efficient technological solutions, ready to react very quickly and to face the emergence of new viruses. Our ambition l
Development of embryonic lymphoid cells that shape the thymic architecture – DELSTAR
The thymus provides the environment for the development and selection of T cells. Thymic epithelial cells coordinate virtually all stages of T cell development, providing key cytokines, chemokines and ligands for the commitment, survival and proliferation of thymocytes and also for positive and nega
The durability of protective immune responses elicited by primary infection with SarS-Cov-2 in patients with rheumatoid arthritis or spondyloarthritis - Impact of immunosuppressive treatments – COVIRIC
Rheumatoid arthritis (RA) and spondyloarthitis (SPA) are the two most common chronic inflammatory rheumatic diseases, with a prevalence of 0.5-1% for RA and about 0.35% for SPA. Many studies have described an increased risk of serious infectious diseases directly associated with increased morbidity
Seasonal detection of Sarbecoviruses in bats from North Vietnam – SO-VIET-BAT
Ten months after the first reported cases of Covid-19 in Wuhan, the origin of the SARS-CoV-2 virus still continues to be debated. In order to avoid other epidemics in the future, it appears crucial to identify the different steps that led to the first human contamination by an animal, in particular
PHOsphorylation TOols for Nucleotides Synthesis – PHOTONS
Nucleoside analogues inhibitors (NAI) play a key role in every approved antiviral therapy in use so far. The situation is unlikely to change drastically in the fight against the SARS-CoV-2 responsible for the COVID-19 pandemic: The NAI Remdesivir is the only approved drug in use so far, but require
Pull the COVID-19 replicative catalytic core apart – PullCoVapart
Antiviral strategies targeting replication machineries have proven their efficacy, with as gold example the cure of HCV patients and to a lesser extent the HIV treatments that control viral load. One of the prerequisites is a detailed knowledge of the structure and function of the multi-protein repl
Umbilical cord-derived mesenchymal stromal cells therapy in SARS-CoV-2-related ARDS – STROMA-CoV2
Whereas the pandemic due do Covid-19 continues to spread, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Severe Acute Respiratory Distress Syndrome in 30% of patients with a 30%-60% mortality rate for those requiring hospitalization in an intensive care unit. The main physio