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PRE-CLINICAL STUDY OF A NEW IMMUNE-CHECKPOINT INHIBITOR IN SARS-COV-2 INFECTION – CLIRCOV
Corona virus disease 2019 (COVID19) is induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and caused over 5 million deaths world-wide in less than two years. Despite intense researches it is not clear how long last the immune responses against SARS-CoV-2 following infection or v
Roles of type I interferons and plasmacytoid dendritic cells in Covid19 – RIPCOV
Specifically, we propose to solve the much debated role of type I interferons (IFN-I) and of plasmacytoid dendritic cells (pDCs) that are the major source of IFN-I during many viral infections. Preliminary results suggest that the response of animals to IFN-I is protective, with respect to both the
New Soidarity and Resilience in times of crisis – NEOSOILID-R
This project focuses on local initiatives eminent in the health, economic and social crisis caused by the coronavirus epidemic. We will focus on “third places” and local initiatives, more or less formal, of pooling and exchange of resources (goods, services, etc.). We will be interested in the way i
Regulating Wetmarkets in Central China : Ethnographic Study of the Perception of Zoonotic Risks after the Covid-19 Crisis – RegWet
Our consortium of French and Chinese social anthropologists will investigate the impact of the Covid-19 crisis on the regulation of wetmarkets in central China. Based on our expertise in the anthropology of human-animal relations in various societies and in the ethnography of the reconstruction of d
Developing a new viro-fluidic technology to explore the viral production from infected cells in real-time at the single-cell and single-particle levels – virofluidics
The goal of this interdisciplinary project is to combine virology to the powerful nano/microfluidic strategies (we called "viro-fluidics") to study, for the first time, the viral egress dynamics at the scales of living single-cells and single-viral nanoparticles. Viro-fluidics will be adapted to stu
Household transmission investigation study for SARS-CoV-2 in French Guiana – EPI-COVID-19
Since December 2019, a new coronavirus, SARS-CoV-2, has been identified in the city of Wuhan in China. By 22 March 2020, the virus had spread to all continents, causing 294 110 confirmed cases and 12 944 deaths worldwide. The detection and spread of this emerging respiratory pathogen are accompanied
Role of type I Interferons and plasmacytoid dendritic cells in the lung immunopathology caused by respiratory viral infections – RIPIREVI
Type I interferons (IFN-I) are key cytokines in vertebrate antiviral defense. However, if excessive or chronic, their production can contribute to the pulmonary immunopathology caused by respiratory infections with influenza (Flu) or coronaviruses. Treatment with glucocorticoids induces a broad immu
Leptin signaling and RNA m6A methylation in acute lung injury: pathways to microvascular barrier protection and therapeutic targets – LAMPS
Acute respiratory distress syndrome (ARDS) is a complex and severe syndrome characterized by an acute lung injury (ALI) without curative treatments. Disruption of lung microvascular barrier and dysregulated inflammation are the central pathophysiological features of ALI common to all ARDS etiologies
Emerging SARS-CoV-2 variants: intersection of entry routes and antiviral responses – VERSATILE
The rapid emergence of numerous SARS-CoV-2 variants poses a global threat to human health and undermines the goal of achieving herd immunity through vaccination. The overarching aim of VERSATILE is to understand the interplay between cell entry routes and host antiviral responses. This will be addre
Functional Interrogation of SARS-CoV-2 RNA-Host Binding Proteins in viral replication – FISHBP
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19 pandemic, which over a span of few month, has caused a devastating global health crisis. In absence of antiviral therapies or approved vaccine, there is an urgent need to understand the molecular interact