Selected – 2015

Transnational call for proposals on Antimicrobial Resistance through the JPI AMR

The ANR joins the Joint Programming Initiative JPI AMR to launch a second transnational call for research projects on Antimicrobial Resistance.

Nine countries are participating in this call for proposals: Argentina, Belgium, France, Germany, Italy, Netherlands, Norway, Poland and Sweden.

The goal of this new call for proposals is to sustain defense against antimicrobial resistance by reviving Neglected and Disused Antibiotics (ND-AB), designing combinations of ND-AB and antibiotic and also designing combinations of ND-AB and non-antibiotic in order to reduce occurrence of resistance or overcome established resistance. The objectives of the call are to repurpose ND-AB and/or identify, characterize and understand interaction between ND-AB and other antibiotics or non-antibiotics used already in the medical setting, in order to find combinations avoiding selection for resistance.

The rationale must be validated through a mechanistic understanding of synergy and/or demonstration of significant improvement of antibiotic use by exploitation of PK/PD characterization. Each project should conclude with a head to head comparison of at least 3 to 6 different treatments in at least two validated animal models. The different in vivo validations from one proposal should be comparable and it is highly recommended to perform them in the same laboratory. The in vivo validation should include some PK/PD analysis. It should incorporate:

  • In vitro demonstration of potential activity by testing ND-AB or ND-AB in combination with other antibiotics or possibly in association with non-antibiotics, to overcome antimicrobial resistance or reduce selection for resistance:
    • Screening combinations and respective dosages of components
    • Sustaining such efficacy by understanding the mechanism involved
  • Strategies to improve PK/PD:
    • On earlier generation antibiotics
    • On combination of antibiotics
  • Validation of the approaches:
    • In vivo, exclusively in validated animal models of infection (preferentially pneumonia, pyelonephritis or endocarditis)
    • Validation including endpoints such as overcoming resistance of multi-resistant strains and/or reduction in selection for resistance or selection of resistance strains/genes.

The scope of the call would exclude:

  • Studies on the resistance of Mycobacterium tuberculosis
  • Studies with antibiotics and non-antibiotics not commercially available for a clinically use and new formulations 
  • Development of new animal models

Each project proposal (pre- and full proposal) must involve a minimum of three and a maximum of six partners from at least three and a maximum of six different participating countries (maximum of two partners per country).

Funding will be awarded for a maximum of three years. The ANR will fund only the French partners in the selected projects.

Open
Closed
Opening : 2015-03-17 at 11h40 CET
Pre-proposal deadline : 2015-05-12 at 17h00 CEST
Application Deadline : 2015-08-25 at 17h00 CEST

SUBMISSION:

This call will be managed by the JPI AMR call office, which is based at ANR, France.

All proposals should be submitted online via the submission website before the respective deadlines (pre-proposals 12 May 2015, 17:00 CET; full proposals 25 August 2015, 17:00 CET).

Each French partner of the selected projects will sign a grant agreement with the ANR. Therefore, he/she will adhere to the methods stipulated in the "Regulations pertaining to the allocation of ANR funding", which may be consulted on the ANR website.

CONTACT

JPI AMR call office

Dr. Serena Battaglia
The French National Research Agency, ANR
50 avenue Daumesnil, 75012 Paris - France
Tel: +33 (0)1 78 09 80 14
JCSAMR(at)agencerecherche.fr

Dr. Martine Batoux
Tel : +33 (0)1 73 54 81 40
JCSAMR(at)agencerecherche.fr

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