Numerical modeling of DNA Electroporation VaccINation – DEVIN

Pulsed electric fields of short duration and high intensities are known to generate conducting structures in both cell and artificial lipid membranes. This phenomenon is referred to electroporation (EP). It has been shown in the 80’s that DNA plasmids can be transferred to cells by mean of EP. Following the booming DNA vaccination, DNA vaccine electroporation (DVEP) has emerged as promising field for the treatments of the future but still lacks physical basis. DEVIN aims to fill up the lack of physical and numerical modeling by tight links between experiments and physics-based models. The goal is to develop a multiphysics multiscale modeling of the DNA uptake from giant unilamellar vesicle -- a relevant biophyiscal models of cell membrane-- to multicellular spheroids. The goal it to propose numerically optimized protocols for DVEP.