CE45 - Interfaces : mathématiques, sciences du numérique – biologie, santé

Anomaly Detection in Multimodal Neuroimaging for the Computer-aided Diagnosis of Dementia – ANO-NEURO

Submission summary

Neuroimaging offers an unmatched description of the brain’s structure and physiology, which explains its crucial role in the understanding, diagnosis, and treatment of neurological disorders, such as dementia. However, identifying subtle pathological changes simply by looking at images of the brain can be a difficult task. This project focuses on the individual analysis of medical images to improve differential diagnosis and prognosis, and strengthen personalised medicine.

The aim of this project is to develop innovative computational imaging tools to model abnormalities, defined as deviations from normal variability, from multimodal brain imaging. To that purpose, deep generative models such as auto-encoders and generative adversarial networks will be used to generate pseudo-healthy images from real patients’ images for different modalities (magnetic resonance imaging, positron emission tomography). Comparing pseudo-healthy and real images will provide individual maps of abnormalities. By extracting the abnormal signal from the images, these abnormality maps will assist clinicians in their diagnosis by providing a clear representation of the pathology. The ability of the proposed method to detect pathologies in images will be evaluated using the abnormality maps as features to feed classification algorithms. Their ability to assist clinical diagnosis will then be assessed, in collaboration with clinical partners from the Paris Brain Institute, by comparing visual interpretations made by clinicians of the original images and of the original images together with the abnormality maps. The methodological developments will be integrated into Clinica and ClinicaDL (www.clinica.run), two open-source software platforms that aim to facilitate the transfer of advanced image analysis and deep learning tools to clinical research.

Project coordination

Ninon BURGOS (Institut du Cerveau)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


ICM Institut du Cerveau

Help of the ANR 272,400 euros
Beginning and duration of the scientific project: February 2024 - 36 Months

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