CE14 - Physiologie et physiopathologie

A new layer in CoA/Ac-CoA metabolism by NME proteins – NME_CoA

Submission summary

The regulated management of the cellular pool of Actyl-Coenzyme A (Ac-CoA) is of critical importance for the life of all organisms. Depending on the energy status of cells, Ac-CoA can be used either in lipid synthesis and storage or in a complex signalling process leading to histone acetylation and transcriptional response of a specific group of genes. We have recently discovered a new regulatory layer based on the identification of an ATP-dependent carrier of cellular Ac-CoA, thus revealing an unsuspected cross-talk between intermediate metabolism and epigenetic regulation. Furthermore, an exciting and completely new concept emerges from our pilot work, which is the intracellular storage of Ac-CoA through abundant specific binding proteins, thus controlling the main pathways of Ac-CoA synthesis/consumption. The present proposal aims to functionally characterise the role of these new findings under different physio-pathological conditions. We believe that the completion of this research programme should pave the way for important conceptual advances in the field of metabolic regulation.

Project coordination

Uwe SCHLATTNER (LABORATOIRE DE BIOENERGETIQUE FONDAMENTALE ET APPLIQUEE (LBFA))

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

LBFA LABORATOIRE DE BIOENERGETIQUE FONDAMENTALE ET APPLIQUEE (LBFA)
IAB Institut pour l'Avancée des Biosciences

Help of the ANR 611,865 euros
Beginning and duration of the scientific project: December 2023 - 48 Months

Useful links

Explorez notre base de projets financés

 

 

ANR makes available its datasets on funded projects, click here to find more.

Sign up for the latest news:
Subscribe to our newsletter