Structure and function of SWI/SNF novel subunits in the DNA damage response – SWING
Accessibility of DNA in chromatin is regulated by ATP-dependent chromatin remodeling complexes. Mammalian SWI/SNF complexes comprise evolutionary conserved core subunits, but also auxiliary subunits that don’t exist in yeast but are integral component of mammalian complex yet poorly defined regulatory roles. Proteins of the BCL7 family are three auxiliary subunits of mSWI/SNF for which the molecular function is currently unknown. Using biochemical, structural and in cellulo approaches, we propose to define their molecular structure and function. We will also study the liquid-liquid phase separation that these proteins undergo. Finally, we will characterize the recruitment of BCL7 proteins at sites of DNA damage and their role in the cellular response to these damages.
Project coordination
Elisa Bergamin (Institut de génétique et de biologie moléculaire et cellulaire (UM 41 - UMR 7104 - UMR_S 1258))
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partner
Epigénétique et destin cellulaire
IGBMC Institut de génétique et de biologie moléculaire et cellulaire (UM 41 - UMR 7104 - UMR_S 1258)
I2BC Institut de Biologie Intégrative de la Cellule
Help of the ANR 616,753 euros
Beginning and duration of the scientific project:
September 2023
- 48 Months
