Metrology for the evaluation of RadioFrequencies biological effects on 3D multicellular models – RF METRO CELL 3D

This project focuses on the assessment of genotoxic and membrane effects of radiofrequency waves on 3D multicellular models of microtissues thanks to the development of a metrology ensuring the calibrated and systematized conditions of application of electromagnetic fields. RF microdevices, which allow to decouple the application of high electromagnetic fields with thermal effect, associated with 3D models of multicellular spheroids allowing the detection of biological effects (membrane permeability, proliferation, genetoxicity, metabolism, oxidative stress…), will be developed and tested while varying different RF parameters (frequency, power, modulation type of electromagnetic waves...). This work will provide precise and quantitative data on the potential impact of electromagnetic fields for public and daily uses (Bluetooth, WIFI and 5G applications notably), and also military "DREP" related issues.