Micro-electrocorticography-based mapping of Dysfunctionning Cognitive networks using evoked high frequency oscillations – MICRODYSCOG

Cortical field oscillations in the high frequency range are associated with normal brain function, but also recognized as a potential biomarker of pathological brain activities. The distinction between these pathological and physiological oscillations is thus crusial for basic research but also to help clinical decisions in resective neurosurgeries of tumours and epilepsy. In the context of intraoperative recordings of awake patients, performed for surgeries in functional areas or maximized tumor resection, our project will investigate a new generation of dense polymer-based microelectrode arrays for recording oscillations at a high spatial and temporal resolution. With these arrays, during standard cognitive tasks, our goal is to identify transient inhibition of stimulus-locked high-frequency responses due to spontaneous pathological oscillations. The localization of these transient inhibitions of cognitive functionning may provide a new biomarker for dysfunctional tissues and can offer clinicians a novel quantitative tool for neurosurgeries.