CE20 - Biologie des animaux, des organismes photosynthétiques et des micro-organismes

A framework to leverage comparative genomics sequence-based data in experimental populations to improve livestock sustainability – FeedSeq

Submission summary

The drops in high-throughput genomic data acquisition costs allow to use them to improve complex and costly traits, such as feed efficiency, a major lever for livestock sustainability. For such traits, genomic data are mainly available in experimental designs. The objective of FeedSeq is to provide a framework to leverage comparative genomics sequence-based data in experimental populations to improve livestock sustainability. To achieve this objective, genomic data from experimental and commercial populations will be supplemented by whole genome sequencing approaches. FeedSeq is organized into five scientific tasks (WP) and two organizational WP, with an open science approach. Beyond data acquisition (WP1), FeedSeq proposes 1. to combine the results of association studies between genomic variants and traits with estimates of adaptive effects of the genomic variants in directional selection experiments (WP2, development of methods; WP3, application to data generated in WP1), 2. to combine the results within species (systems genetics) and between species (translational genetics) to gain power across all designs (WP4). From these results, the gains in precision of genomic prediction in commercial populations thanks to the consolidated effects of the genomic variants will be quantified, and new predictive measures of feed efficiency will be proposed to consolidate the selection currently carried out on this trait (WP5). The target species in FeedSeq are pigs and rabbits, for which original and complementary experimental lines are available. This PRCE project is a collaboration between an INRAE laboratory (experts in quantitative genetics, population genetics and molecular genetics), the French pig and rabbit breeders and the IFIP-Institut du Porc, to respond to axis A.3 of the 'AAP ANR 2022.

Project coordination

Hélène Gilbert (Institut national de la recherche en agronomie)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

GenPhySE Institut national de la recherche en agronomie
HYPHARM
GeT-PlaGe Institut national de recherche pour l'agriculture, l'alimentation et l'environnement
HYCOLE
Alliance R&D
IFIP-INSTITUT DU PORC

Help of the ANR 584,131 euros
Beginning and duration of the scientific project: February 2023 - 48 Months

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