Causative genetic alterations in human meiotic arrest and their correction – MEIOBLOC
Homogeneous meiotic arrest is a rare condition that prevents sperm formation or accelerated ovarian exhaustion, resulting in infertility for which there is no treatment today. Recent results confirm genetic heterogeneity, but there is currently no standardized description of the testicular phenotype, nor functional validation of the genetic variants identified. The objective of the MEIOBLOC project, following the establishment of a national network, is to better define the arrests of spermatogenesis and to confirm the functional impact of the male and female variants identified through the development of mouse and cell models. Finally, several gene therapy approaches aiming at restoring spermatogenesis in mouse models of meiotic arrest will be considered in order to evaluate the feasibility and safety of this approach for possible clinical application.
Project coordination
François VIALARD (Biologie de la Reproduction, Environnement, Epigénétique & Développement)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partnership
BREED Biologie de la Reproduction, Environnement, Epigénétique & Développement
GABI Génétique Animale et Biologie Intégrative
BREED Biologie de la Reproduction, Environnement, Epigénétique & Développement
SGCSR Stabilité Génétique, Cellules Souches et Radiations
IGC Intégrité du génome et cancer
Help of the ANR 647,852 euros
Beginning and duration of the scientific project:
March 2023
- 48 Months
