CE07 - Chimie moléculaire

High-Valent Copper-Oxygen Species for the Activation of inert C-H bonds – COSACH

Submission summary

This proposal aims at developing new copper-based mononuclear and dinuclear catalysts for C-H bond activation in alkanes. The architecture of these new catalysts will be based on the recent experimental and theoretical investigations on bioinspired models of copper-monoxygenases (LPMO and pMMO). In particular, the project will focus on the generation and in-situ characterization of transient reactive [Cu(II)O•-]+, [Cu(III)OH]2+, [Cu2(III,II)bis(?-oxo)]… species, by using original techniques such as cryo-spectroelectrochemistry and sequential-collisions mass spectrometry. The project covers different fields including synthesis/characterization of new ligands/complexes, generation and identification of the targeted species supported by theoretical calculations, and catalytic studies for substrate oxidation. COSACH is a fundamental research project, which results will certainly impact the field of hydrocarbons oxidation and/or remediation, and more generally in oxidase/oxygenase mimicry.

Project coordination

Nicolas Le Poul (Université de Brest)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


CEMCA Université de Brest
CNRS DR12_ISM2 Centre National de la Recherche Scientifique Délégation Provence et Corse _ISM2

Help of the ANR 457,809 euros
Beginning and duration of the scientific project: September 2022 - 48 Months

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