CE06 - Polymères, composites, physico-chimie de la matière molle

MOF-decorated polymer monolith in sequential microcolumn for Enantioselective Catalysis and in-line Separation in continuous flow – ECaSep

Submission summary

The aim of this project is to address issues encountered in continuous flow enantioselective catalysis related to mass transfer limitations, catalyst immobilization guarantying high catalytic site density while maintaining both good enantioselectivity and high activity as well as the real-time monitoring of the reaction progress by creating innovative hybrid sequential microreactors based on the combination of macroporous polymer monoliths (MPMs) and chiral metal-organic frameworks (MOFs). Herein, the association of two distinct types of porous materials will lead to devices where the intrinsic properties of each material will be optimally exploited: the large pores of MPMs will ensure a fast mass transport while the large surface area, substantial pore volumes and chiral properties of homochiral MOFs will afford the adequate environment within which catalytic sites will be stabilized. The high internal surface area of the MOFs will be exploited to efficiently disperse palladium nanoparticles, used as catalytic species. Directly following the first catalytic section, a second microcolumn, filled with MPMs whose surface is functionalized with optically active chemical functions, will be devoted to an in-line separation section that will allow the real-time monitoring of the catalyst efficiency. The catalytic performances of the microcolumns will be assessed by applying cross-coupling asymmetric reactions, i.e., involving arylboronic acid derivatives and allyl halides with a chiral carbon to generate strategically important intermediate to synthesize drugs, agrochemicals and biologically active molecules. The creation of these microsystems will be made possible by the symbiotic collaboration of Dr Julien Reboul, an expert in MOF composites and their use as catalysts, and Dr Benjamin Carbonnier with his team, who has been investigated MPM over the last 15 in silica capillary or microchips, notably as metallic catalysts’ supports for continuous flow processes.

Project coordination

Julien Reboul (Laboratoire de Réactivité de Surface)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

ICMPE Institut de Chimie et des Matériaux Paris-Est
LRS Laboratoire de Réactivité de Surface

Help of the ANR 311,229 euros
Beginning and duration of the scientific project: December 2022 - 42 Months

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