Résilience - COVID-19 - Résilience - Coronavirus disease 2019

Study of the relationship between spectral and metabolic abnormalities and virological characteristics of CoV-2-SARS in COVID-19 patients with neurological disorders – SPECTRO-VIRO-COVID

Submission summary

Despite a growing number of publications, post-COVID-19 neurological disorders remain relatively little studied by magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) and their varied radiological semiology remains insufficiently described. It is important to evaluate the complications of COVID-19 on the nervous system in order to identify and understand the cerebral anomalies that may be responsible for neurological symptoms, sometimes persistent ("COVID-19 long", WHO recommendations in February 2021) in COVID-19 patients. Within the framework of a project initiated in September 2020 at the CHU Amiens-Picardie "N-SPECTRO-COVID" (https://clinicaltrials.gov/ct2/show/NCT04546737), we have preliminary results on neurological damage in COVID-19 patients, highlighting morphological (MRI) and spectral and metabolic (MRS, with a higher sensitivity than MRI) changes that may explain certain underlying pathological processes and their evolution over time (follow-up). In the current pandemic context, we propose to study the relationships between virological and immunological characteristics and spectral and metabolic data of brain damage in COVID-19 patients with neurological symptoms. In addition, the impact of new CoV-2-SARS mutations on neurological damage, their severity and their persistence (or not) will also be studied. We hypothesise that the spectral and metabolic profile measured (by MRS) in COVID-19 patients, prior to the emergence of new variants, would be different in COVID-19 patients with one of the new variants of CoV-2-SARSS: 20I/501Y.V1 (UK), 20H/501Y.V2 (South Africa), 20J/501Y.V3 (Brazil) and the Bavarian variant.

Project coordination

Jean Marc CONSTANS (CHUAP)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

CHUAP

Help of the ANR 78,400 euros
Beginning and duration of the scientific project: April 2021 - 12 Months

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