Understanding Keloid Disorders: A multi-scale in vitro/in vivo/in silico approach towards digital twins of skin organoids on the chip – S-Keloid

Mathematical and numerical modelling approaches allow us to integrate pathological processes that occur across different scales: cell, cells assembly, and tissue. The S-Keloid project aims to investigate the role of mechanical and inflammatory environmental factors on cells associated with keloid disorders. To address the multiscale aspects of these disorders, we plan to combine and integrate 3D in vitro cell models cultured under mechanical and biological stresses in order to mimic in vivo situation, and mathematical modelling of such systems. From applying experimental tests at tissue-scale and using a multiscale approach, the mechanical stress fields will be integrated into the 3D mathematical model. Parameter identification, optimization and their use across multiple scales will ensure the realism of the models and the quantitative and qualitative predictions of the keloid disorder.