Multiplexed Wireless Localization and Powering of Ingestible Microdevices with Bio-adaptive Wave Control Technologies – MedWave

Wireless ingestible devices can non-invasively access major organs along the gastrointestinal tract for diagnosis and therapy. Recent advances in sensors and electronics permit microdevices that can sense their environment, release drugs, and perform biopsies, but existing wireless solutions remain limited in their ability to localize and power such devices. These limitations result from challenges in controlling electromagnetic waves in the human body – a dynamic, heterogeneous, lossy, and dispersive medium. The objective of this proposal is to develop adaptive wave control technologies that overcome these challenges to enable precise localization and efficient powering of ingestible microdevices. To accomplish this, we will (i) elucidate wave control mechanisms using complex anatomic models, (ii) develop wearable arrays for localization and adaptive powering, and (iii) demonstrate clinical utility by mapping gastrointestinal bleeding in a porcine model. These goals align with the research priority “Applications of digital technologies in the fields of health, sustainable mobility and sustainable cities” of the ANR–NRF bilateral agreement within the 2021 call for proposals (ANR theme 8.7 “Healthcare technologies”). The strong synergy of expertise and know-how at NUS (bioelectronics) and IETR (electromagnetics, antennas) will jump-start the next generation of wireless microdevices for diagnostics and therapy.