Development of a 3D in vitro model to mimic the osseo- and soft tissue-integration process of dental implants – IDEAL-3D

The aim of this project is to fabricate and evaluate an in vitro 3D model representative of the processes of osseointegration and soft tissue integration of dental implants, using Bioprinting techniques, in order to serve as a reliable and reproducible platform for research in implant dentistry. In the same model, an alveolar bone model, a gingival tissue model and a dental implant will be combined: this combination represents the main originality of the model. The development of this model will offer a new tool for basic and clinical researchers, to better understand dental implants integration physiology and peri-implantis development, and to evaluate new biomaterials and drugs. This model will enhance the relevance of in vitro studies, and reduce the use of animal experiments. The research consortium comprises 4 research groups specialized in Tissue engineering, implant dentistry, immunology and bioprinting, as well as a French company in implant dentistry