genotype/phenotype correlations to alloW rupturE risk stratification of intraCranial Aneurysm – WECAN

Intracranial aneurysms (IAs) affect 3% of the population and IA rupture is a devastating event (40% mortality). The ICAN biobank includes 3400 IA patients with clinical, imaging and DNA. WECAN relies on this exceptional resources for rupture risk stratification among IAs. WP1 uses image processing tools for automatic and morphological characterization of the brain vessels. This will allow an objective characterization of IA. WP2 exploits the whole ICAN population by sequencing a panel of susceptibility genes and genotyping SNPs.WP3 crosses multimodal data to build a predictive model of IA sub-phenotypes and stratify the risk of IA rupture. Quantitative traits extracted from imaging will be cross-analyzed through advanced deep learning strategies with the clinical and genetics data. This strategy has never been performed to date for IAs. The IA pathology will benefit from personalized, precision medicine and FAIR big data analysis, leveraging open science best practices.