EMULBIONT: Impact of dietary food additive EMULsifiers on pathoBIONT’s pathogenic potential in chronic inflammatory diseases: from mechanism to prevention – EMULBIONT

Accumulating evidences revealed that disturbances of the host-microbiota relationship can results in microbiota encroachment which associates with the promotion of chronic intestinal inflammation. For example, we observed that consumption of dietary emulsifiers leads to alterations in microbiota that associate with increased colitis severity and metabolic deregulations in mice. Emulsifier-induced microbiota alterations are necessary and sufficient to promote inflammation, and we more recently demonstrated that specific microbiota members, yet to be identified, are required to drive the detrimental effects of emulsifiers. The EMULBIONT project will built upon these previous observations to identify bacteria, as well as molecular mechanisms, driving emulsifier-induced chronic inflammation. We anticipate that completion of this project will provide important knowledge on mechanisms by which select food additives can shape a pro-inflammatory microbiota, with the ultimate goal to provide microbiota-based personalized nutrition.