Pathophysiological role and plasticity of skin-projecting nociceptors in two major chronic skin disorders – NOMINATION

Atopic dermatitis (AD) and Psoriasis (Pso) are frequent chronic inflammatory skin conditions that affect around 7% and 3% of adults, respectively. These two diseases are driven by different (almost antagonist) immune responses, i.e a type 2 immune response for AD and a type 1/17 immune response for Pso. Recent pre-clinical studies have suggested that nociceptive sensory neurons (nociceptors – which transmit itch and pain messages) could actively participate in the development of the inflammatory response in both diseases, but their precise role is still elusive. In this study, we will combine expertise in neuro-immunology, transcriptomic and chemogenetic to study the role played by nociceptors in chronic mouse models of AD and Pso. This work should shed new lights on the plasticity and function of skin-projecting nociceptors in two important dermatoses and help to identify new “neuro-immune-oriented” therapeutic opportunities.