Assessment of SARS-CoV-2 obstetric, fetal, and neonatal risk with study of placental and circulating extracellular vesicles in pregnant women serum exposed to SARS-CoV-2 during COVID-19 pandemic – COroFET
Information on SARS-CoV-2 infection risks in pregnant women and their offspring has so far been limited to small case series. Our objective is to explore from a large clinical-biological cohort, the obstetric, fetal and neonatal repercussions of SARS-CoV-2 and understand its pathophysiological mechanism. Our study will have four components; i) assessment of maternal-fetal transmission in women exposed to SARS-CoV-2, ii) assessment of obstetric, fetal, and neonatal SARS-CoV-2 risks, iii) study of women exposed to SARS-CoV-2 placenta with histological, immunohistochemical and transcriptomic comparison, and iv) study of placental extracellular vesicles composition in pregnant women serum according to their infection status. These 4 combined components will provide a better understanding of pathophysiological mechanisms of SARS-CoV-2 infection in pregnant women.
Project coordination
Anne BROUCHET (CHU Toulouse)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partnership
CHUT CHU Toulouse
INFINITy Institut Toulousain des Maladies Infectieuses et Inflammatoires
CERPOP Centre d'Epidémiologie et de Recherche en santé des POPulations de Toulouse
DEFE Développement Embryonnaire, Fertilité et Environnement
Help of the ANR 442,756 euros
Beginning and duration of the scientific project:
September 2021
- 30 Months
