CE07 - Chimie moléculaire

Securing a bright future for the emerging SF5 chemistry – SulFive

Submission summary

The pentafluorosulfanyl group is a truly new functional group introduced to organic chemists in the last decades. The paucity of hypervalent fluorinated sulfur-containing molecules is the result of unfavourable factors that are the poor availability of reagents for the introduction of the SF5 group, the lack of activation modes for SF5Cl or the notoriously inertness SF6, the absence of generalised methods to access ?6-pentafluorosulfanes, and thus a poor availability of SF5-containing building blocks, specifically aliphatic SF5 ones. We propose several levers of innovation to tackle the major bottlenecks that impede the bright future of SF5 chemistry. We hypothesize that new activation modes together with the design of safe reagents can be used to generate an extensive portfolio of novel SF5 compounds (WP1). Successful implementation of this fundamental research will create a sound foundation for the asymmetric construction of novel chiral non-racemic molecular architectures (WP2).

Project coordination

Dominique Cahard (CHIMIE ORGANIQUE, BIOORGANIQUE : RÉACTIVITÉ ET ANALYSE)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

UMR 7042 Laboratoire d'Innovation Moléculaire et Applications (LIMA)
COBRA CHIMIE ORGANIQUE, BIOORGANIQUE : RÉACTIVITÉ ET ANALYSE

Help of the ANR 396,356 euros
Beginning and duration of the scientific project: December 2021 - 48 Months

Useful links

Explorez notre base de projets financés

 

 

ANR makes available its datasets on funded projects, click here to find more.

Sign up for the latest news:
Subscribe to our newsletter