CE06 - Polymères, composites, physique et chimie de la matière molle, procédés

Emerging Dynamics of Janus particle Engulfment by biomimetic Membranes (EDEM) – EDEM

Submission summary

Understanding and controlling colloid engulfment by membranes is relevant in drug delivery, microbial infections and toxicity from nanomaterials. In EDEM we aim at achieving a fine control on Janus microparticle engulfment and penetration inside giant lipid vesicles as cell model systems. Beyond particle engulfment, we will also explore active vesicle transportation and membrane disruption by localized photothermal effects. To this purpose, we will engineer multifunctional (magnetic and plasmonic) colloidal Janus particles able to self-propel if powered by light and be guided by magnetic fields. These microparticles asymmetrically covered by plasmonic nanoparticles will be fabricated by droplet based microfluidics. Partial and complete particle engulfment by membranes will be achieved varying both the particle (Janus particle morphology, nanoparticle size, surface chemistry) and the lipid bilayer (membrane spontaneous curvature, charge, fluidity) physicochemical properties.

Project coordination

Antonio Stocco (Institut Charles Sadron (UPR 22))

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

I.C.S Institut Charles Sadron (UPR 22)
PHENIX PHysicochimie des Electrolytes et Nanosystèmes InterfaciauX

Help of the ANR 368,054 euros
Beginning and duration of the scientific project: - 48 Months

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