CE12 - Génétique, génomique et ARN

Evolutionary role of archaic genomic inheritance in the unique Melanesian human diversity – PapuaEvol

Submission summary

Part of our genome does not come from Homo sapiens but from extinct lineages, the archaic hominins. This project determines the function of this exceptional biological inheritance in the unique human diversity of New Guinea Island. Globally, these populations have the highest proportion of inherited genes from these mysterious ancestors (up to 5%), such as Denisovans, but the consequences of these admixtures remain poorly understood. By combining a multidisciplinary approach from anthropological genetics to cutting-edge functional genomics, this project will identify the biological contribution of this archaic introgression to the genetic adaptation of the immune system of Melanesians. It will be a cornerstone for future research on human genomics due to its methodology and the results it will generate on the evolutionary pressures that have acted upon these groups in the last 50 thousand years.

Project coordination

Francois-Xavier RICAUT (EVOLUTION ET DIVERSITE BIOLOGIQUE)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

University of Massey / School of Fundamental Sciences
University of Melbourne / Centre for Systems Genomics
University of Papua New Guinea / School of Humanities & Social Sciences,
EDB EVOLUTION ET DIVERSITE BIOLOGIQUE
University of Tartu / Institute of Genomics

Help of the ANR 347,247 euros
Beginning and duration of the scientific project: November 2020 - 42 Months

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