Antimicrobial peptides nanodelivery systems based on Aptamers/Mesoporous silica nanoparticles – ALES

The excessive use of antibiotics has led to emergence of bacteria strains, which are resistant to a range of antimicrobials, including first-choice agents for the treatment of humans. By 2050, the death toll caused by the antimicrobial resistance could exceed the one related to cancer and diabetes combined. In light of this emergency, antimicrobial peptides have the potential to become valuable antimicrobial weapons because they offer potential broad-spectrum and rapid bactericidal activity. However, their toxicities and poor specificities limit their clinical use. To overcome these drawbacks, we will develop hybrid delivery systems based on aptamers and mesoporous silica nanoparticles. Very high in vitro antimicrobial activities with very high specificities are expected.