CE07 - Chimie moléculaire

Copper fluorescent ligands: for a rational design of Cu-targeting drugs in Alzheimer context – Copperation

Submission summary

"Copperation" project aims to develop and synthesize fluorescent ligands capable of selectively extract copper (I) ions (Cu) contained in the amyloids-ß peptides (Aß), thus inhibit the production of toxic reactive oxygen species (ROS) in the context of Alzheimer's disease. The fluorescence properties will allow (i) in cellulo complex localization studies of these molecules; (ii) mechanistic studies during the extraction processes of Cu from Aß and during the evaluation of the impact of the ligands on ROS production (in vitro and in cellulo). The ability of ligands to rebalance Cu between intra- and extracellular compartments for therapeutic purposes will also be studied, as well as their effects on restoring cell survival under or without oxidative stress.

Project coordination

Charlène ESMIEU (LABORATOIRE DE CHIMIE DE COORDINATION)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

LCC LABORATOIRE DE CHIMIE DE COORDINATION

Help of the ANR 230,904 euros
Beginning and duration of the scientific project: November 2020 - 48 Months

Useful links

Explorez notre base de projets financés

 

 

ANR makes available its datasets on funded projects, click here to find more.

Sign up for the latest news:
Subscribe to our newsletter