CE07 - Chimie moléculaire

Carbon Dioxide: C1 source for Fluoroalkylation by Deoxyfluorination – CDI-Deox

Submission summary

The trifluoromethyl group is recognized to pervade all aspects of chemical research. For more than a century efforts have been made to enhance the accessibility of the trifluoromethyl group. In the course of this period, research into new trifluoromethylating reagents has grown and evolved in remarkable ways. Among those the Ruppert-Prakash reagent (CF3TMS) is by far the most used. However, the manufacture of CF3TMS incorporates ozone-depleting chemicals. To overcome this drawback we aim to develop a new concept based on the use of carbon dioxide as C1 feedstock and a deoxyfluorinating reagent. The first phase of the project relies on the use of pure organic chemistry for the trifluoromethylation of amines and alkynes. The second phase involves more fundamental research applying transition metal catalysis. Both parts are complementary and target a substantial contribution to a more responsible way of conducting trifluoromethylation reactions
The establishment of such a concept will enable exceptional trifluoromethylation reactions. Moreover, it constitutes a breakthrough in fluorine chemistry and will definitely pave the way to industrial applications.

Project coordination

Anis Tlili (INSTITUT DE CHIMIE ET BIOCHIMIE MOLECULAIRES ET SUPRAMOLECULAIRES)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

ICBMS INSTITUT DE CHIMIE ET BIOCHIMIE MOLECULAIRES ET SUPRAMOLECULAIRES

Help of the ANR 200,880 euros
Beginning and duration of the scientific project: November 2020 - 48 Months

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