Exploring the contribution of sex chromosomes to male/female differences in aging and longevity – LongevitY

This proposal focuses on the differences in longevity between males and females in animals (including humans). The origin of these differences is not well understood. Here we want to explore the role of sex chromosomes. Having a single X or a Y may have consequences on male aging and lifespan. This proposal, which includes experts in ecology, genomics and biomedical research, relies on a multi-approach strategy mixing comparative biology, genetics and genomics. We propose to study 1) the relationship between sex chromosomes and longevity at the level of mammals and birds, 2) the effect of XY chromosomes on longevity in 5 drosophila species, 3) the effect of XY chromosomes on longevity of patients with XY aneuploidies. This proposal will lead to a better understanding on differences in longevity between sexes and provide the data necessary for developing anti-aging interventions adapted to sex.