Concomitant IDentification, Antibiotic REsistance characterization and Virulence evaluation of bacteria using adaptive targeted mass spectrometry – IDAREV
MALDI-TOF mass spectrometry has revolutionized pathogen identification by shortening this step by 24h compared to traditional biochemical tests. In contrast, the antibiotic therapy choice remains largely driven by conventional antibiotic susceptibility testing, hence with a delay of 18-24h after ID. Commercially available products exist today for quicker determination of resistance determinants, either based on imaging, molecular biology tools, or on colorimetric and immuno-chromatographic testing. There is however no universal technology available for rapid (t<6hrs), cost effective, concomitant ID, AST characterization and virulence evaluation. By leveraging on an innovative in-real-time adaptive targeted mass spectrometry technology, we propose to overcome this limitation, directly from a positive blood culture, and with a time-to-result of less than an hour.
Project coordination
Jérome Lemoine (Institut des Sciences Analytiques)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partnership
ISA Institut des Sciences Analytiques
M2iSH MICROBES, INTESTIN, INFLAMMATION ET SUSCEPTIBILITÉ DE L'HÔTE
CNR_RAB_EPC Structure, Dynamique, Fonction et Expression de béta-lactamases à larges spectres
CNR_RAB_Enc CNR Résistance aux Antibiotiques (laboratoire associé ''Entérocoques'')
CIRI CENTRE INTERNATIONAL DE RECHERCHE EN INFECTIOLOGIE
CHRONO CHRONO-ENVIRONNEMENT
Help of the ANR 543,999 euros
Beginning and duration of the scientific project:
October 2019
- 42 Months
