CE09 - Nanomatériaux et nanotechnologies pour les produits du futur

Microfluidic devices incorporating miRNA capture, release and matricial electrochemical detection modules – Dimelec

Submission summary

The Dimelec project combines the skills of several laboratories for the development of a new methodology for treatments and rapid analyzes of biological samples adapted for emergency diagnosis. The objective is to design an analysis platform combining microfluidics, nanobiotechnologies (synthesis and functionalization of nano-objects) and electrochemistry (synthesis / materials, reactivity / microelectrodes and electronics / instrumentation) for the multiassay of microRNA circulating in the blood. These new markers are specific for certain pathologies and an early detection in the blood is a source of information on the progress of a disease and allows a rapid management of the patient. The chosen strategy is the combination of different steps for an analysis platform capable of: (i) pre-treating the biological sample (ii) capturing targeted microRNAs using magnetic nanoparticles (NPS) functionalized (iii) to release microRNA captured by controlled magnetic hyperthermia (local heating, without overall increase in the temperature of the medium) and finally (iv) to detect them in functionalized microelectrode arrays. The multi-detection will be made possible thanks to an instrument adapted to microelectrode arrays in terms of specificities and ergonomics of use, equipment that does not currently exist for dedicated applications coupling electrochemistry and microfluidics. Beyond this application in the field of medical diagnosis, the instrumentation that will be developed will respond to an instrumental lack and will be valuable to the communities of microfluidicists and electrochemists, especially for applications dedicated to environmental sciences (pesticides, drugs, metals heavy) and health (antibodies, nucleic acids, protein-drugs interactions, enzymes, …).

Project coordination

Jean GAMBY (Centre de Nanosciences et de Nanotechnologies)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

UMR-MD-1197 Interactions cellules souches niches: physiologie, tumeurs, réparations tissulaires
LISE Laboratoire Interfaces et Systèmes Electrochimiques
C2N Centre de Nanosciences et de Nanotechnologies
PHENIX PHysicochimie des Electrolytes et Nanosystèmes InterfaciauX

Help of the ANR 407,465 euros
Beginning and duration of the scientific project: December 2019 - 42 Months

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