Regulation of nucleic acid innate sensing by TLR trafficking from the cell to the mouse level – TraToll

Insights into the functioning of the innate immune system are crucial to be able to design appropriate immunotherapies. However, we still lack basic knowledge regarding the regulation of innate sensing by nucleic acid sensors named endosomal Toll-Like Receptors (TLRs). Our project aims at deciphering the molecular mechanisms governing the regulation of nucleic acid sensing by endosomal TLRs through the control of their intracellular trafficking. Focusing on TLR3, we will study important molecular players to determine how and where TLR3 traffics, meets its ligand and signals. This knowledge will be transposed in a mouse model of TLR3-dependent and antigen specific immune response. The control of innate immune receptor signalling through their trafficking is a relatively nascent field that shows immense potential for the discovery of molecules that could precisely control signaling and the downstream immune response during immunotherapeutic strategies