DS0402 - Décryptage des fonctions biologiques élémentaires et de leur intégration

Understanding planar polarization of centrioles in multiciliated epithelia – ORICEN

Submission summary

Arrays of cilia beating at the surface of multiciliated epithelia drive cerebrospinal fluid circulation in the brain, mucus clearance in the airway, and egg transportation along the oviduct. Impairment of this function can lead to severe conditions, such hydrocephalus, chronic sinusitis and respiratory infections, bronchiectasis, and female infertility. Beating orientation depends on the polarization within the plane of the plasma membrane of centrioles, from which cilia are assembled, but how this is achieved is not well understood.
In planarian flatworms, an emerging model organism for which a large experimental toolkit is already available, multiciliated cells are required for locomotion. Screening by RNA interference for genes affecting planarian locomotion, we identified genes controlling centriole rotational polarity and uncovered a novel mechanism connecting centriole structure to tissue polarity. In ORICEN, we will address how these conserved proteins influence planar polarization of centrioles in multiciliated cells, using a unique combination of approaches involving flatworms and Xenopus laevis. We expect our research to highlight fundamental cellular mechanisms of development, and homeostasis: the integration of cellular structures within overall organism polarity. This work will also point out to possible disease genes and mechanisms associated to ciliopathies, potentially providing new biomarkers for their diagnosis.

Project coordination

Juliette Azimzadeh (Institut Jacques Monod)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


IJM Institut Jacques Monod
CNRS IBDM UMR 7288 Centre National de la Recherche Scientifique délégation Provence et Corse - Institut de Biologie du Développement

Help of the ANR 412,673 euros
Beginning and duration of the scientific project: November 2015 - 36 Months

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